Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-04-24 Cooperative journals: 《中国全科医学》
Abstract： Background In the face of the serious challenges posed by the high prevalence of chronic diseases among the elderly and the coexistence of multiple chronic diseases，the health problems of community-dwelling elderly people' with multimorbidity require urgent attention. The comorbidity management model is being explored and practiced. Disease experience，as self-reported health information from patients，is expected to become a key component of the patient-centered community multimorbidity management model. Objective This study aimed to gain a deeper understanding of the real disease experience of community-dwelling elderly people with multimorbidity and provide a basis for personalized health management and supportive strategies of the group. Methods This study used purposive sampling and maximum difference sampling to select eligible interviewees from four communities under the jurisdiction of a community health service center in Zhengzhou City from August to September in 2022. Based on the principle of information saturation，20 subjects were ultimately included. Based on the research objective，literature review，and expert consultation results，the preliminary interview outline was formulated， and the final interview outline was determined after interviewing 2 patients. Semi-structured interviews were conducted with the study participants，guided by the phenomenological research methodology. Golaizzi analysis was used to analyse the data. Results Four themes and eleven sub-themes had been extracted from this study，including mainly long-standing symptomatic distress（physical dysfunction，fatigue，sleep disorders，and pain），negative psychological experiences （feelings of helplessness and worry about future life，reduced sense of social value and self-identity，and loneliness with altered social activities）， positive mindset of coexisting harmoniously with multimorbidity（being grateful for being satisfied，and positively adapting）， and aspirations in times of adversity（hoping for improvement in functioning，and seeking multi-directional social support）. Conclusion Physical dysfunction，sleep disturbances，fatigue，and pain are the most concerning health disturbances for community-dwelling elderly people with multimorbidity. The symptom management and multiple social support of the multimorbidity need to be strengthened. In the future，it is expected that multidimensional data would be used for dynamic health assessment to explore the common and individual patterns of multimorbidity，and to achieve precise management and intervention of elderly multimorbidity in the community.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-06-09 Cooperative journals: 《中国全科医学》
Abstract： Background Trauma is a highly prevalent and costly global health problem. prevention and control of infection is a major challenge in the management of traumatic wounds，while prolonged absence of skin washing after trauma will increase the incidence of wound infection，as well as the discomfort. Although many patients are willing to take a bath after trauma，the timing and method of bathing remains unclear. Therefore，it is necessary to build an appropriate scheme of bathing with wounds to keep the skin and wounds clean. Objective To construct a bathing with wounds at home scheme suitable for patients with traumatic wounds in China，and to provide a feasible care scheme for keeping the skin of trauma patients clean and improving the outcome of wound healing. Methods Database at home and abroad were searched to obtain original literature，the first draft of the items of bathing with wounds at home scheme for patients with traumatic wounds was formulated through evidence#2;based analysis，generalization，group discussion. Fifteen wound care experts with associate or higher titles were included，and Delphi consultation was used to modify and improve the bathing with wounds scheme，with an interval of one week for each round of correspondences，the reliability of the consultation results was evaluated by the expert positive and authority coefficients. The consistency of the consultation results was evaluated by the coefficient of variation，a revised draft was formulated with terminated consultation when the coefficient of variation less than 0.25，which means that the expert opinions tend to be consistent. Thirty patients with traumatic wounds were enrolled in the pre-test，Likter 5-point scale was used to verify the convenience，safety and patient compliance of the bathing with wounds scheme，and the final scheme was developed after discussion and modification. Results After the inclusion of 23 related papers，the first draft of bathing with wounds scheme was developed through evidence#2;based analysis and discussion，involving three first-level items（including preparation befor bathing，bathing operation and treatment after bathing），eight second-level items，nine third-level items and three fourth-level items. The opinions of the 15 experts converged after 2 rounds of correspondence，with recall rates of 93.75% and 100%，with authority coefficients of 0.947 and 0.957，respectively. The variation coefficients of importance and maneuverability of each item in the first round were 0~0.25 and 0~0.23，and those in the second round were 0.09-0.18 and 0.07-0.14，respectively，a total of 2 items were deleted，5 items were modified and 2 items were added，resulting in a revised draft. The 30 enrolled patients with traumatic wounds took baths （2.70±0.47） times per week according to the bathing scheme.，with the average bath time of 10~15min，convenience and compliance scores of （4.67±0.48） and （4.70±0.47），and no bathing-related adverse events and wound infection occurred. Conclusion In the construction process of the bathing with wounds scheme for traumatic wound patients，the positive and authority coefficients of experts are high，which has been unanimously approved by corresponding experts. The compliance of 30 patients with traumatic wounds in the pre-test was high，suggesting that the bathing with wounds scheme is safe and convenient，which can be applied to bathing with wounds at home for patients with traumatic wounds in China.
Subjects: Environmental Sciences, Resource Sciences >> Basic Disciplines of Environmental Science and Technology submitted time 2020-11-20 Cooperative journals: 《干旱区地理》
Abstract：秦岭为我国气候分界线和南水北调中线重要水源地，太白山为其最高峰，了解太白山区域的 过去干湿变化特征对气候变化机制研究和未来水资源持续利用具有重要意义。基于秦岭太白山地区太白红杉树木年轮资料及其附近的宝鸡、眉县气象站1959—2016年气象数据进行分析，重建了1852—2016年春季（3～5月）SPEI值，分析了近165 a太白山春季干湿变化特征及其与大尺度环流变化关系。结果表明：（1）太白山地区太白红杉径向生长主要受春季气候限制；与春季SPEI值相关性最高，达到－0.72（P＜0.01），重建方程方差解释量为51.8%（调整自由度后为51.0%）。（2）重建结果表明，近165 a来，有29 a春季为湿润年份，有23 a春季为干旱年份，分别占比为17.58%和13.94%。极端干旱年份为1892年、1929年、1945年和2006年，极端湿润年份为1881年、1921年和1990年，其中1892年（－1.73）和1881年（1.53）分别为最干旱和最湿润的年份。（3）重建结果得到了周边地区干湿变化重建结果和历史文献灾害记载的验证；太白山地区干湿变化可以准确表征大区域干湿变化且存在2.5 a、3.1 a、3.8 a和8.4 a周期变化。太白山地区SPEI与赤道东太平洋海面温度成负相关以及与赤道西太平洋海面温度呈正相关，其干湿变化可能与ENSO活动有关。
Subjects: Biology >> Bioengineering submitted time 2017-06-01 Cooperative journals: 《中国生物工程杂志》
Abstract： There are strong evidences to support the idea that follicle-stimulating hormone (FSH) plays an important role in regulation of bone mass. Owing to its limited expression to gonadal tissues and osteoclasts and its precursor monocytes, FSH receptor may be a good target for FSH blocking therapy. In this study, high titers of polyclonal rabbit anti-human FSHR antibody (pAbFSHR) was raised and prepared. The bilateral ovariectomized (OVX) Sprague-Dawley (SD) rats were used as the osteoporosis model for evaluating the effects of pAbFSHR and FSH inhibitor leuprorelin(LE) on the bone loss. The results showed after treatment with pAbFSHR and LE separately, the FSH and luteinizing hormone(LH) levels in OVX groups decreased significantly (p<0.05) compared with PBS treated OVX rats. No significant differences of estrogen (E2) levels were detected between treatment and PBS injected OVX rats (P > 0.05). In addition, the number of trabecular bone increased after pAbFSHR treatment in OVX groups in the shin bone histologic analysis. The results suggested targeting against FSHR may work on the treatment of osteoporosis.
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