Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-08-29 Cooperative journals: 《中国全科医学》
Abstract： Background In the context of the deep integration of information technology with various industries，as well as the strong promotion of the development of smart healthcare by the country，the management of chronic diseases in community has also been gradually explored and transformed from the traditional mode to the informationized and intelligent management mode. In the case of deep aging gradually，it is necessary to clarify whether informationized chronic disease management is effective for the elderly population. Objective To understand the role of mobile network in the management of chronic diseases in the elderly，so as to provide reference for research on informationized management of related chronic diseases. Methods Using convenience sampling method，a total of 650 elderly hypertensive patients registered with community health service centers in four communities under the jurisdiction of Linghe District，Jinzhou City were selected as study subjects from January to July 2022. The study subjects were divided into the intervention group and control group based on the principle of prioritizing the proximity of living location under informed voluntary consent，with 325 cases in each group. The control group was treated with routine community chronic disease management and face-to-face follow-up once every two months. The intervention group was treated with network hypertension management based on the control group，with an intervention of 6 months. The effects were evaluated using the Hypertension Knowledge Level Scale（HK-LS），Therapeutic Adherence Scale for Hypertensive Patients（TASHP），and Hypertension Patients Self-Management Behavior Rating Scale（HPSMBRS），and a satisfaction survey was conducted. Results After the intervention，the scores of HK-LS，TASHP and HPSMBRS dimensions in the intervention group were higher than those in the control group（P<0.05）; 93.5% （275/294）of the older adults believed that mobile network-assisted hypertension management facilitated access to medical care，86.4%（254/294） believed that it saved the cost of medical care，and 80.6%（237/294） believed it facilitated condition monitoring. Further survey of the factors affecting the effect of management were mainly physical factors，psychological factors，and dissatisfaction with hardware and software equipment. Conclusion Mobile network assisted hypertension management in community can effectively improve the knowledge level，treatment compliance，and self-behavior management ability of elderly patients with hypertension，with high level of satisfaction.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2018-01-25 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To explore the relationship between waist-to-hip ratio (WHR) and chronic kidney disease (CKD) in non-diabetic subjects and compare the difference between male and female subjects. Methods We performed a cross-sectional survey among 2142 community-based southern Chinese participants without diabetes from June to October 2012. We divided all the participants into 4 groups according to the gender-specific quartiles of WHR. Logistic regression models were used to explore the associations of WHR with CKD in these subjects. Results In the unadjusted model, WHR was significantly associated with CKD in women (OR=7.29, 95% CI: 3.56-16.32, P<0.001), and the association was still significant (OR=6.13, 95% CI: 2.56-15.20, P=0.003 ) after adjustment for the potential confounders (including age, history of hypertension, coronary heart disease, current smoker, physical inactivity, education level, systolic blood pressure, diastolic blood pressure, serum triglyceride, serum high density lipoprotein, blood glucose, and BMI). The odds ratio (OR) for having CKD in the highest versus lowest quartile of WHR levels was 2.44 (95% CI: 0.98-4.97, P=0.103) in men in the unadjusted model. Conclusion WHR levelsareassociatedwithCKDinnon-diabeticwomenbutnotinnon-diabeticmalesubjects.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate the value of serum IgA/C3 ratio in the diagnosis of IgA nephropathy and explore its relationship with the clinicopathological features of the patients. Methods Sixty-six patients with IgA nephropathy, 111 with other glomerular diseases, and 40 healthy control subjects without kidney disease were tested for serum IgA and C3 levels using CRM470 adjusted standardized immune turbidimetric method, and the IgA/C3 ratio was calculated. According to Oxford and Lee's classification criteria, we analyzed the pathological grades of the renal biopsy samples from patients with IgA nephropathy. The ROC curve was used to assess the value of serum IgA and IgA/C3 ratio in predicting IgA nephropathy. Results Patients with IgA nephropathy had an elevated serum IgA/C3 ratio than those with other glomerular diseases and the control subjects, with an area under the ROC curve of 0.776. An elevated serum IgA/C3 ratio was not found to significantly correlate with the pathological grade of renal biopsy samples in patients with IgA nephropathy. Conclusion In the absence of renal biopsy findings, serum IgA/C3 ratio can help in the diagnosis of IgAnephropathy.
Subjects: Biology >> Bioengineering submitted time 2017-07-24 Cooperative journals: 《中国生物工程杂志》
Abstract： Construction of human SP-B protein transgenic mice and bacterial pneumonia model
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