Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-09-28
Song, Xiaochen
Zhang, Hui
Zhong, Sen
Tan, Xianjie
Ma, Shuiqing
Jin, Ying
Pan, Lingya
Wu, Ming
Cao, Dongyan
Yang, Jiaxin
Xiang, Yang
Abstract： Objective: The current treatment for early-stage neuroendocrine carcinoma of the cervix (NECC) mainly relies on radical hysterectomy and chemotherapy. The routine use of postoperative radiation is still in controversial. We want to evaluate the value of postoperative radiation in early-stage NECC.
Methods: A retrospective cohort study. Early-stage NECC patients from 2006 to 2022 in Peking Union Medical College Hospital were included. Depending on whether the patients received radiation therapy after surgery, they were divided into Postoperative non-radiation group (Group A) and Postoperative radiation group (Group B). We use Kaplan-Meier method to analyze the progression-free survival (PFS), overall survival (OS), recurrence and OS rate.
Results: Sixty-six cases were included, 32 (48.5%) in Group A and 34 (51.5%) in Group B. After 35 (range 12-116) months follow-up, 26 (39.4%) experienced recurrence. Compared with Group A, Group B had lower pelvic recurrence rate (12.5% vs 2.9%, p = 0.142), slightly higher distant recurrence rate (28.1% vs 44.1%, p = 0.177), and similar mortality rate (29.4% vs 31.3%, p = 0.871). Cervical stromal invasion ≥1/2 was more common in Group B (28.0% vs 63.0%, p = 0.012). Postoperative radiation in patients with cervical stromal invasion ≥1/2 showed an extended trend in PFS (33.9 months vs 47.9 months) and OS (40.7 months vs 70.0 months) but without statistical difference (p = 0.963, p = 0.636). Lymph-vascular space invasion (LVSI) is a high-risk factor for tumor recurrence (HR 9.13, p = 0.005), but radiation after surgery did not improve the PFS (51.5 months vs 48.8 months, p = 0.942) and OS (53.9 months vs 60.6 months, p = 0.715) in patients with LVSI.
Limitations: The limitations of this study are the retrospective nature and relative small sample size.
Conclusions: Postoperative radiation seems to prolong PFS and OS in patients with cervical stromal invasion ≥1/2. LVSI was a high-risk factor for tumor recurrence, but radiation after surgery in patients with LVSI seems have no survival benefits.
Peer Review Status:
Awaiting Review
Subjects: Library Science，Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/Significance] The technical patent in the field of library is an important representation of the technical development of library. It is used as the unit of measurement to form one of the important dimensions to observe the overall development and reform of library. By combing the evolution of patents in the field of library, we can better explore and grasp the law of library development.[Method/Process] This paper analyzed the time, patentee, subject distribution and change law of patents in the field of library, and compared them with the multiple dimensions of library development policies and library research literatures.[Result/Conclusion] Based on the analysis of library related patents, it is found that the related technologies are mainly oriented to "physical books" and "convenient librarians' daily application". In recent years, more and more attention has been paid to the "user" scenario, and the artificial intelligence technology has also increased rapidly in recent years. In the multi-dimensional comparison of library development, themes in related fields at the levels of technology, research and policy show asynchrony.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2018-04-08 Cooperative journals: 《协和医学杂志》
Abstract：随着医学的进步和手术器械设备日益更新改善，机器人手术作为一种新兴的微创手术方式逐渐应用于妇科领域，与开腹手术及传统腹腔镜手术相比，具有三维视野高清、机械臂可自由旋转、操作精细准确、学习曲线短等优势。
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