Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-05-14 Cooperative journals: 《中国全科医学》
Abstract： Day care service is an important component of the community care service system for elderly people with dementia. However，the concept of dementia day care has not been unified，and its connotation and implementation framework have not been clarified，which greatly affects the continuous construction and high-quality service supply of dementia day care service. The Walker classic concept analysis method was used and five attributes of the concept was introduced including（1） daytime intensive，non-residential care；（2）professional coordination and integrated care focused on families with dementia； （3）public respite care support for families with dementia；（4）a crucial complement to high-quality care for dementia；（5） a driving force in promoting a dementia-friendly community. The preconditions of dementia day care include high care needs， weakened family functions and the dominant role of public care，and the consequences involve dementia，family caregivers and social welfare. The implementation factors identification，implementation strategy design，implementation and effect evaluation were carried out respectively using the consolidated framework for implementation research，the replicating effective programs implementation framework and the RE-AIM evaluation framework in the field of implementation science. The specialization， high quality，integrated care，and the philosophy of the friendly community should be highlighted in the future development of dementia day care. The service content，facilities and implementation process need to be improved to promote the quality of dementia day care service.
Subjects: Psychology >> Cognitive Psychology submitted time 2024-02-27
Abstract： Alzheimer’s disease (AD) is very common and is associated with a high mortality rate. Therefore, exploring the mechanisms of the onset and development of amnestic mild cognitive impairment (aMCI), a clinical prodromal stage of AD, can help prevent the disease. Previous studies have suggested a close relationship between memory decline in aMCI and multiple executive domain defects; however, key scientific questions, such as which executive domain is the key pathogenic factor, remain unanswered, and key intervention targets remain unknown. To overcome the limitations of previous studies that considered executive function as a whole or fragmented element, this study will focus on the overall structure of executive function based on the hypothesis that executive function in aMCI is associated with memory impairment. This study will use electroencephalography (EEG) technology to investigate the time domain, time-frequency, and dynamic brain network characteristics of three sub-components of executive function (inhibition, updating, and switching) in patients with aMCI. Using a three-dimensional convolutional neural network, specific neural targets of executive function defects will be identified, and the possibility of adding neural markers related to the inhibition domain for early identification of aMCI will be explored. In addition, the effects of training and the neural basis of different targeted digital interventions in patients with aMCI will be analyzed using a longitudinal design, thus revealing the crucial role of the inhibition domain-related frontal-parietal control network in the interventions. This study aims to elucidate inhibition as a new cognitive target for aMCI executive function defects and explore interventions from the perspective of computational cognitive neurology. It also aims to provide evidence-based support for the early identification, precise diagnosis, and development of treatment plans for aMCI.
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