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  • Nrf1 acts as a highly-conserved determinon for maintaining robust redox homeostasis in the eco-evo-devo process of life histories

    Subjects: Biology >> Molecular Biology submitted time 2024-05-24

    Abstract: Differential and even opposing functions of two major antioxidant transcription factors Nrf1 and Nrf2 (encoded by Nfe2l1 and Nfe2l2, respectively) are determined by distinctions in their tempospatial positioning, topological repartitioning, proteolytic processing, and biochemical modification, as well as in their shared evolutionary origin. As a matter of fact, the allelopathic potentials of Nrf1 and Nrf2 (both resembling two entangled ‘Yin-Yang’ quanta that comply with a dialectic law of the unity of opposites) are fulfilled to coordinately control redox physiological homeostasis so as to be maintained within the presetting thresholds. By putative exponential curves of redox stress and intrinsic anti-redox capability, there is inferable to exist a set point at approaching zero with the ‘Golden Mean’ for the healthy survival (i.e., dubbed the ‘zero theory’). A bulk of the hitherto accumulating evidence demonstrates that the set point of redox homeostasis is dictated selectively by multi-hierarchical threshold settings, in which the living fossil-like Nrf1 acts as a robust indispensable determinon, whereas Nrf2 serves as a versatile chameleon-like master regulon, in governing the redox homeodynamic ranges. This is attributable to the facts that Nrf2 has exerted certain ‘double-edged sword’ effects on life process, whereas Nrf1 executes its essential physiobiological functions, along with unique pathophysiological phenotypes, by integrating its ‘three-in-one’ roles elicited as a specific triplet of direct sensor, transducer and effector within multi-hierarchical stress responsive signaling to redox metabolism and target gene reprogramming. Here, we also critically reviewed redox regulation of physio-pathological functions from the eco-evo-devo perspectives, through those coding rules (redox code, stress-coping code, and topogenetic code). The evolving concepts on stress and redox stress were also further revisited by scientific principles of physics and chemistry, apart from two novel concepts of ‘oncoprotists’ and ‘reverse central dogma’ being introduced in this interdisciplinary and synthetic review.

  • A Catalog of 13CO Clumps from the MWISP in l = 10°–20°

    Subjects: Astronomy >> Astrophysical processes submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: In this study, we present a catalog of molecular clumps extracted from 13CO (J = 1 − 0) emission data of the Milky Way Imaging Scroll Painting (MWISP) project. The data covers the inner Milky Way within the longitude range 10° ≤ l ≤ 20° and the latitude strip of . The workflow for the extraction of clumps, namely Facet-SS-3D-Clump, consists of two parts: the identification of clump candidates and their verification. First, Facet-SS-3D-Clump employs FacetClumps to identify clump candidates. Subsequently, high-confidence clumps are obtained by cross-matching with the clumps detected by other algorithms, such as dendrogram. Second, these high-confidence clumps are used as prior knowledge to train a semi-supervised deep clustering approach, SS-3D-Clump, which is applied to verify clump candidates detected by FacetClumps, providing confidence levels for the molecular clumps. Finally, the catalog comprising 18,757 molecular clumps was obtained using Facet-SS-3D-Clump, and the catalog is 90% complete above 37 K km s−1. We observe a significant deviation of the mean Galactic latitude for clumps within ∣b∣ ≤ 2° from the midplane, with . We found that 82.3% of the dust clumps correspond to 13CO clumps by matching with Herschel infrared dust clumps. In the future, Facet-SS-3D-Clump will be applied to detect 13CO clumps in the entire MWISP data.

  • Spectral Index Distribution of Various Scale Components in Supernova Remnant Cassiopeia A

    Subjects: Digital Publishing >> New Media submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: Cassiopeia A (Cas A) is a well-known candidate for studying cosmic-ray acceleration, in which compact features of various scales have attracted much attention. Based on observations by the Very Large Array of Cas A at 6 cm and 21 cm, we measure the spectral index distribution of various scale components using the observation of the 1998 epoch. We decompose its total density image into nine scale components, and map the temperature spectral index distribution of each component, which ranges from −2.48 ± 0.01 to −2.91 ± 0.05. We find that the spectral indices increase from the small scale to large scale components. A damped post-shock magnetic field model with a strength larger than ∼200 μG and a damping length scale less than ∼10% of the remnant radius can account for the spectral index variation naturally.

  • Capture Efficiency Analysis in the Circular Restricted Three-body Problem

    Subjects: Digital Publishing >> New Media submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: Temporary capture efficiency is studied in the framework of the circular restricted three-body problem in two steps. First, a non-uniform distribution of test particles around the secondary's orbit is obtained by fully accounting the secondary's gravitational influence. Second, the capture efficiency is computed based on the non-uniform distribution. Several factors influencing the result are discussed. By studying the capture efficiency in the circular restricted three-body problem of different mass ratios, a power-law relation between the capture efficiency (p) and the mass ratio (μ) is established, which is given by p ≈ 0.27 × μ0.53, within the range of 3.0035 ×10−6 ≤ μ ≤ 3.0034 × 10−5. Taking the Sun–Earth system as an example, the influence from the orbit eccentricity of the secondary on the non-uniform distribution and the capture efficiency is studied. Our studies find that the secondary's orbit eccentricity has a negative influence on the capture efficiency.

  • Low Surface Brightness Galaxies from BASS+MzLS with Machine Learning

    Subjects: Digital Publishing >> New Media submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: The distribution of the LSBGs is bimodal in the g − r color, indicating the two distinct populations of the blue (g − r < 0.60) and red (g − r > 0.60) LSBGs. The blue LSBGs appear spiral, disk or irregular while the red LSBGs are spheroidal or elliptical and spatially clustered. This trend shows that the color has a strong correlation with galaxy morphology for LSBGs. In the spatial distribution, the blue LSBGs are more uniformly distributed while the red ones are highly clustered, indicating that red LSBGs preferentially populate a denser environment than the blue LSBGs. Besides, both populations have a consistent distribution of ellipticity (median ), half-light radius (median reff ∼ 4'') and Sérsic index (median n = 1), implying the dominance of the full sample by the round and disk galaxies. This sample has definitely extended the studies of LSBGs to a regime of lower surface brightness, fainter magnitude and broader other properties than the previously Sloan Digital Sky Survey-based samples.

  • BSEC Method for Unveiling Open Clusters and its Application to Gaia DR3: 83 New Clusters

    Subjects: Digital Publishing >> New Media submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: Open clusters (OCs) are common in the Milky Way, but most of them remain undiscovered. There are numerous techniques, including some machine-learning algorithms, available for the exploration of OCs. However, each method has its limitations and therefore, different approaches to discovering OCs hold significant values. We develop a comprehensive approach method to automatically explore the data space and identify potential OC candidates with relatively reliable membership determination. This approach combines the techniques of Hierarchical Density-Based Spatial Clustering of Applications with Noise, Gaussian mixture model, and a novel cluster member identification technique, color excess constraint. The new method exhibits efficiency in detecting OCs while ensuring precise determination of cluster memberships. Because the main feature of this technique is to add an extra constraint (EC) for the members of cluster candidates using the homogeneity of color excess, compared to typical blind search codes, it is called Blind Search-Extra Constraint (BSEC) method. It is successfully applied to the Gaia Data Release 3, and 83 new OCs are found, whose color–magnitude diagrams (CMDs) are fitted well to the isochrones. In addition, this study reports 621 new OC candidates with discernible main sequence or red giant branch. It is shown that BSEC technique can discard some false negatives of previous works, which takes about three percentage of known clusters. It shows that as an EC, the color excess (or two-color) constraint is useful for removing fake cluster member stars from the clusters that are identified from the positions and proper motions of stars, and getting more precise CMDs, when differential reddening of member stars of a cluster is not large (e.g., ΔE(GBP − GRP) < 0.5 mag). It makes the CMDs of 15% clusters clearer (in particular for the region near turnoff) and therefore is helpful for CMD and stellar population studies. Our result suggests that the color excess constraint is more appropriate for clusters with small differential reddening, such as globular clusters or older OCs, and clusters that the distances of member stars cannot be determined accurately.

  • Real-time Abnormal Detection of GWAC Light Curve based on Wavelet Transform Combined with GRU-Attention

    submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: Nowadays, astronomy has entered the era of Time-Domain Astronomy, and the study of the time-varying light curves of various types of objects is of great significance in revealing the physical properties and evolutionary history of celestial bodies. The Ground-based Wide Angle Cameras telescope, on which this paper is based, has observed more than 10 million light curves, and the detection of anomalies in the light curves can be used to rapidly detect transient rare phenomena such as microgravity lensing events from the massive data. However, the traditional statistically based anomaly detection methods cannot realize the fast processing of massive data. In this paper, we propose a Discrete Wavelet (DW)-Gate Recurrent Unit-Attention (GRU-Attention) light curve warning model. Wavelet transform has good effect on data noise reduction processing and feature extraction, which can provide richer and more stable input features for a neural network, and the neural network can provide more flexible and powerful output model for wavelet transform. Comparison experiments show an average improvement of 61% compared to the previous pure long-short-term memory unit (LSTM) model, and an average improvement of 53.5% compared to the previous GRU model. The efficiency and accuracy of anomaly detection in previous paper work are not good enough, the method proposed in this paper possesses higher efficiency and accuracy, which incorporates the Attention mechanism to find out the key parts of the light curve that determine the anomalies. These parts are assigned higher weights, and in the actual anomaly detection, the star is detected with 83.35% anomalies on average, and the DW-GRU-Attention model is compared with the DW-LSTM model, and the detection result f1 is improved by 5.75% on average, while having less training time, thus providing valuable information and guidance for astronomical observation and research.

  • The Multi-parameter Test of Gravitational Wave Dispersion with Principal Component Analysis

    Subjects: Digital Publishing >> New Media submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: In this work, we consider a conventional test of gravitational wave (GW) propagation which is based on the phenomenological parameterized dispersion relation to describe potential departures from General Relativity (GR) along the propagation of GWs. But different from tests conventionally performed previously, we vary multiple deformation coefficients simultaneously and employ the principal component analysis (PCA) method to remedy the strong degeneracy among deformation coefficients and obtain informative posteriors. The dominant PCA components can be better measured and constrained, and thus are expected to be more sensitive to potential departures from the waveform model. Using this method we analyze ten selected events and get the result that the combined posteriors of the dominant PCA parameters are consistent with GR within 99.7% credible intervals. The standard deviation of the first dominant PCA parameter is three times smaller than that of the original dispersion parameter of the leading order. However, the multi-parameter test with PCA is more sensitive to not only potential deviations from GR but also systematic errors of waveform models. The difference in results obtained by using different waveform templates hints that the demands of waveform accuracy are higher to perform the multi-parameter test with PCA. Whereas, it cannot be strictly proven that the deviation is indeed and only induced by systematic errors. It requires more thorough research in the future to exclude other possible reasons in parameter estimation and data processing.

  • Cluster Analysis of the Roma-BZCAT Blazars

    Subjects: Digital Publishing >> New Media submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: Based on the collected multiwavelength data, namely in the radio (NVSS, FIRST, RATAN-600), IR (WISE), optical (Pan-STARRS), UV (GALEX), and X-ray (ROSAT, Swift-XRT) ranges, we have performed a cluster analysis for the blazars of the Roma-BZCAT catalog. Using two machine learning methods, namely a combination of PCA with k-means clustering and Kohonen's self-organizing maps (SOMs), we have constructed an independent classification of the blazars (five classes) and compared the classes with the known Roma-BZCAT classification (FSRQs, BL Lacs, galaxy-dominated BL Lacs, and blazars of an uncertain type) as well as with the high synchrotron peaked (HSP) blazars from the 3HSP catalog and blazars from the TeVCat catalog. The obtained groups demonstrate concordance with the BL Lac/FSRQ classification along with a continuous character of the change in the properties. The group of HSP blazars stands out against the overall distribution. We examine the characteristics of the five groups and demonstrate distinctions in their spectral energy distribution shapes. The effectiveness of the clustering technique for objective analysis of multiparametric arrays of experimental data is demonstrated.

  • Digitization of Astronomical Photographic Plates of China and Astrometric Measurement of Single-exposure Plates

    Subjects: Digital Publishing >> New Media submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: From the mid-19th century to the end of the 20th century, photographic plates served as the primary detectors for astronomical observations. Astronomical photographic observations in China began in 1901, and over a century, a total of approximately 30,000 astronomical photographic plates were captured. These historical plates play an irreplaceable role in conducting long-term, time-domain astronomical research. To preserve and explore these valuable original astronomical observational data, Shanghai Astronomical Observatory has organized the transportation of plates, taken during nighttime observations from various stations across the country, to the Sheshan Plate Archive for centralized preservation. For the first time, plate information statistics were calculated. On this basis, the plates were cleaned and digitally scanned, and finally digitized images were acquired for 29,314 plates. In this study, using Gaia DR2 as the reference star catalog, astrometric processing was carried out successfully on 15,696 single-exposure plates, including object extraction, stellar identification, and plate model computation. As a result, for long focal length telescopes, such as the 40 cm double-tube refractor telescope, the 1.56 m reflector telescope at Shanghai Astronomical Observatory, and the 1m reflecting telescope at Yunnan Astronomical Observatory, the astrometric accuracy obtained for their plates is approximately 

  • Astronomical Test with CMOS on the 60 cm Telescope at the Xinglong Observatory, NAOC

    Subjects: Astronomy >> Astrophysical processes submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: This work shows details of an evaluation of an observational system comprising a complementary metal-oxide-semiconductor detector, 60 cm telescope and filter complement. The system's photometric precision and differential photometric precision, and extinction coefficients were assessed through observations of Supersky flat fields, open clusters, standard stars and exoplanets. Photometry was precision achieved at the 0.02 mag level, with differential photometry of 0.004 mag precision. Extinction was found to agree with previous studies conducted at Xinglong Observatory. Ultimately, the results demonstrate this observing system is capable of precision scientific observations with a charge-coupled device across the optical wavelengths.

  • New Vacuum Solar Telescope Achieves Narrowband Infrared Solar Imaging Observation at He i 10830 Å

    Subjects: Astronomy >> Astrophysical processes submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: The near-infrared imaging channel constitutes a crucial component of the multichannel high-resolution imaging system of the New Vacuum Solar Telescope (NVST). We have successfully achieved high-resolution, narrowband imaging of the chromosphere using He i 10830 Å triplet within this channel, which significantly enhances the imaging observation capabilities of NVST. This paper provides a concise overview of the optical system associated with the near-infrared imaging channel, detailing data processing procedures and presenting several observed images. Leveraging a high-resolution image reconstruction algorithm, we were able to generate a narrowband image near the diffraction limit at 10830 Å with a temporal resolution of less than 10 s.

  • First Digit Distributions of Gamma-Ray Bursts

    Subjects: Astronomy >> Astrophysical processes submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: The occurrence of the first significant digits from real world sources is usually not equally distributed, but is consistent with a logarithmic distribution instead, known as Benford's law. In this work, we perform a comprehensive investigation on the first digit distributions of the duration, fluence, and energy flux of gamma-ray bursts (GRBs) for the first time. For a complete GRB sample detected by the Fermi satellite, we find that the first digits of the duration and fluence adhere to Benford's law. However, the energy flux shows a significant departure from this law, which may be due to the fact that a considerable part of the energy flux measurements is restricted by lack of spectral information. Based on the conventional duration classification scheme, we also check if the durations and fluences of long and short GRBs (with duration T90 > 2 s and T90 ≤ 2 s, respectively) obey Benford's law. We find that the fluences of both long and short GRBs still agree with the Benford distribution, but their durations do not follow Benford's law. Our results hint that the long–short GRB classification scheme does not directly represent the intrinsic physical classification scheme.

  • Dust Condensation of SiC, SiO in Asymptotic Giant Branch Stellar Winds-SiC Spectrum

    Subjects: Digital Publishing >> New Media submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: We have chosen the Large Scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) code to calculate the coalescence of silicon carbide (SiC), silicon oxide dust (SiO) in the AGB stellar wind. LAMMPS is a classical molecular dynamics simulation code. At the same time, we consider the effect of temperature on the evolution of molecular dynamics. We also calculated the temperature change of non-spherical SiC, SiO dust coalescence. The condensation temperature range of SiC dust in the AGB stellar wind is [300–500]k and [900–1100]k for SiO. Finally, the infrared spectrum of SiC was calculated using Gaussian 16 software. The 77SiC, 70Si3C3, and 121Si3C3 models have clear characteristic peaks of infrared spectra responding at 5, 8.6, 11.3, 15, 19, and 37 μm.

  • First Light Curve Analysis of NSVS 8294044, V1023 Her, and V1397 Her Contact Binary Systems

    Subjects: Digital Publishing >> New Media submitted time 2024-05-24 Cooperative journals: 《Research in Astronomy and Astrophysics》

    Abstract: The first photometric light curve investigation of the NSVS 8294044, V1023 Her, and V1397 Her binary systems is presented. We used ground-based observations for the NSVS 8294044 system and Transiting Exoplanet Survey Satellite data for V1023 Her and V1397 Her. The primary and secondary times of minima were extracted from all the data, and, by collecting the literature, a new ephemeris was computed for each system. Linear fits for the O − C diagrams were conducted using the Markov Chain Monte Carlo (MCMC) method. Light curve solutions were performed using the PHysics Of Eclipsing BinariEs Python code and the MCMC approach. The systems were found to be contact binary stars based on the fillout factor and mass ratio. V1023 Her showed the O'Connell effect, and a cold starspot on the secondary component was required for the light curve solution. The absolute parameters of the system were estimated based on an empirical relationship between orbital period and mass. We presented a new T–M equation based on a sample of 428 contact binary systems and found that our three target systems were in good agreement with the fit. The positions of the systems were also depicted on the M–L, M–R, q–Lratio, and Mtot–J0 diagrams in the logarithmic scales.

  • Chinese Expert Consensus on Grassroots Prevention and Treatment of Hypertension Combined with Type 2 Diabetes Mellitus and Dyslipidemia in Adults 2024

    Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2024-05-24 Cooperative journals: 《中国全科医学》

    Abstract: Hypertension,Diabetes,and Dyslipidemia are collectively referred to as the three highs ,which often coexist in the same individual. It significantly increasing the risk of hospitalization,death,and related burdens for patients. So it is necessary to jointly control the risk and standardize the treatment. Primary healthcare institutions have become the main battlefield for the prevention and treatment of chronic diseases. Existing clinical evidence provides important insights into the prevention,treatment,and management of the three highs ,but there are no applicable norms,consensus,and guidelines for the co-management of the three highs in primary healthcare institutions at domestic and foreign. Four academic organizations led by Beijing Hypertension Association organized primary healthcare workers and invited experts and scholars from many fields such as cardiovascular,endocrine,pharmacy,and public health services to participate in the consensus. It widely soliciting clinical practice needs of primary healthcare workers,integrating and evaluating the evidence related to the prevention and treatment of the three highs in primary healthcare institutions. After multiple rounds of discussions,revisions,and voting,the consensus for primary healthcare in the prevention and treatment of the three highs was formed,which includes 21 recommended opinions. The recommended opinions of this consensus aim to improve the awareness and ability of primary healthcare workers in the prevention and treatment of the three highs ,and provide scientific strategic support,implement management with primary healthcare characteristics,and lay a solid foundation for comorbidity co-management.

  • Quantitative Analysis of China’s Contracted Family Doctor Service Policies Based on a Three-Dimensional Analysis Framework

    Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2024-05-24 Cooperative journals: 《中国全科医学》

    Abstract: Background  After being completely promoted for less than seven years,China’s contracted family doctor service work still faces a number of development problems. The primary obstacle impeding the work of contracted family doctor service is an inadequate guarantee mechanism. There is an urgent need for scientific and reasonable policies on contracted family doctor service to guarantee the effective development of the work. Objective  To quantitatively analyze the textual content of China’s contracted family doctor service policies,to explore the focus and shortcomings of the existing policies,and to provide the basis and reference for the development and optimization of the subsequent contracted family doctor service policies. Methods  Policy texts were collected by visiting the official websites of the China government and the National Health Commission of the People’s Republic of China on 2023-01-10,and 15 policy texts on contracted family doctor service from 2015-01-01 to 2022-12-31 were selected to construct a three-dimensional analytical framework of policy tools-stakeholders-policy strength,to categorize,code,and analyze the policy documents. Results  Supply-based,demand-based,and environment-based tools accounted for 30.5%(69/226),19.0%(43/226),and 50.5%(114/226) of the policy tool dimension. Family doctors,contractors,non-contractors,primary medical and health care institutions,hospitals(secondary and above),and the government accounted for 29.2%(123/422),14.7%(62/422),9.2%(39/422),21.3%(90/422),13.3%(56/422),and 12.3%(52/422) of the stakeholder dimension. The average strength of China’s contracted family doctor service policies was 2.2 points. In the cross-dimension of policy tools-stakeholders,the distribution of stakeholders in supply-based and environment based tools was relatively poor. There were some sub-tools that were absent from the policy tools. In the cross-dimension of policy tools-policy strength,environment-oriented policy instruments were used more often as policy strength increased. In the cross dimension of stakeholders-policy strength,there were large differences of the policy strength matching scores among various stakeholders. Family doctors had the highest score(311 points) with non-contractors the lowest score(90 points). Conclusion  From the perspective of policy tools,policy tools should be allocated rationally,with the weight of use continuously adjusted,the internal structure optimized,and the rationality of the distribution of policy tools among stakeholders improved. From the stakeholder’s perspective,all stakeholders should be taken into account,their respective positions need to be clarified,and the demand of the non-contractors should be emphasized. From the perspective of policy strength,the policy supervision and management capacity ought to be strengthened to continuously improve the implementation of the policy of contracted family doctor service.

  • Clinical Observation of the New Antiepileptic Drug Perampanel in the Treatment of Refractory Epilepsy in Children Aged 0-18 Years

    Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-05-23 Cooperative journals: 《中国全科医学》

    Abstract: Background  Currently,the treatment of refractory epilepsy(RE)in children is still a difficult point in epilepsy treatment. In China,pirenzapine(PER)is still a new drug for treating RE in children,and there is currently a lack of recommendations for adding PER to the treatment of RE in children. And in Chinese reports,the sample size of RE patients treated with PER is relatively small. Therefore,the efficacy of PER for pediatric RE,especially for young children with RE,still needs to be further studied with a large sample size. Objective  To explore the efficacy,possible indications,adverse reactions,and tolerability of PER addition therapy for RE in children. Methods  A self-control and retrospective analysis was conducted on children with RE aged 0-18 who were treated at the Women and Children's Hospital affiliated with Qingdao University from January 2022 to January 2023. The frequency of seizures at different observation points before and after the addition of PER treatment was compared,and the effective rate of PER was evaluated. Adverse drug reactions and drug retention rates were recorded,and the clinical characteristics of the effective and ineffective groups of PER were analyzed. Result  A total of 192 study subjects were included. After adding PER treatment,the effective rates at 12,24,and 36 weeks were 56.3%(108/192),62.1%(113/182),and 69.7%(122/175),respectively,and the seizure free rates were 19.3%(37/192),21.4%(39/182),and 24.6%(43/175). The incidence of adverse reactions was 16.1%(31/192),mainly including dizziness,irritability,weakness,and drowsiness. The last follow-up drug retention rate was 91.1%(175/192). There was a statistically significant difference(P<0.05)in the onset age,duration of anti-epileptic treatment,type of origin,seizure form,frequency of seizures before the addition of PER,number of combined anti-epileptic drugs(ASMs),and ketogenic diet/surgical treatment between patients with RE who received continuous medication for 12 weeks. In addition,178 children underwent EEG examination,and 167 children underwent cranial magnetic resonance imaging examination. There was a statistically significant difference (P<0.05)in the electroencephalogram(EEG)and head magnetic resonance imaging(MRI)results between patients who received effective and ineffective treatment. In the results of electroencephalogram examination,the effective rate of discharge in the anterior(anterior,middle,temporal anterior,and middle)part of the brain is higher;In the results of cranial imaging examination,the normal group had a higher effective rate,followed by children with mainly white matter damage. Conclusion  The overall effective rate and retention rate of PER addition therapy for RE in children are high,with mild adverse reactions and good drug tolerance. It is more effective for children with RE who have a late onset age,seizures in the form of motor seizures,focal origin,short course of anti-epileptic treatment,fewer combination medications,and less frequency of seizures. In electroencephalography,patients with normal discharge in the anterior(anterior,middle,anterior temporal,and middle temporal)of the brain and normal results in cranial magnetic resonance imaging have a higher effective rate.

  • Effects of Programmatic Assessment in Clinical Reasoning Courses in General Practice

    Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2024-05-23 Cooperative journals: 《中国全科医学》

    Abstract: Background  The clinical reasoning of general practitioners is the key to providing quality medical services to patients,but it is not suitable for traditional methods to evaluate this ability because it is an abstract ability that cannot be directly observed. Objective  This paper aims to improve the efficiency of general practitioners' clinical reasoning training and enrich the evaluation of medical education by optimizing the evaluation method of curriculum teaching. Methods  From September to December 2022,38 master's degree students of the Medical School of Tongji University were divided into the in-service group(16) and residential training group (22). The course consists of three modules,namely core,case and result,and adopts blended teaching method to carry out teaching. The content of quantitative evaluation is different kinds of rating scale,while the content of subjective evaluation comes from multi-source feedback. SPSS 22.0 was used for statistical analysis. Results  The final course scores for the core and case modules were statistically significant for both groups(P<0.05),but the first course scores were not(P>0.05). The quantitative evaluation scores of the whole class and the two groups of students in the first and last courses of the above two modules were compared,and there was statistical significance (P<0.001). Subjective evaluation can be divided into positive evaluation and improvement evaluation. It is found that with the deepening of the course,the number and percentage of positive evaluation of core modules and case modules continue to rise,while the number and percentage of improvement evaluation continue to decline. Conclusions  Programmatic assessment can enrich the evaluation system of general clinical reasoning,promote students' construction of general clinical reasoning in order,and also found that "flipped classroom" is a form of procedural evaluation.

  • 一例老年慢性心力衰竭合并房颤患者的心脏康复之路

    Subjects: Nursing >> Nursing submitted time 2024-05-22

    Abstract:本文总结一例慢性心力衰竭合并房颤患者通过治疗及心脏康复护理恢复心功能的经验。早期识别病情变化,提高风险预判能力,结合患者的需求,病情观察,生活护理,心理护理,健康指导的基础上,通过心脏康复“五大处方”,中医护理技术,腹式呼吸训练,下肢肌肉力量训练,有效改善临床症状,有效预防并发症,使患者改善生活质量,回归正常生活。