Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2022-08-17 Cooperative journals: 《中国全科医学》
Abstract: General practice research often pays attention not only to the physical health of patients, professional competence of doctors, and the quality of medical services, but also to the spiritual feelings of patients, motivation of doctors to practice, and the cooperation between doctors and patients. However, these are not resolved well only using quantitative research which is still dominated in the field of general practice. Mixed methods research which integrates qualitative and quantitative research, combining the advantages of both, can analyze specific problems more broadly and in depth, and increase the generalizability of research results, which is suitable for studying complex problems. However, the application of mixed methods research in general practice is still limited in China, and the standardization of its design and implementation needs to be improved. Therefore, this paper plans to introduce the key points in the design and implementation of mixed methods research from methodological lence, combining theory with practice, so as to provide reference for general practitioners who intend to carry out mixed methods research.
Subjects: Biology >> Bioengineering Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics submitted time 2017-02-13
Abstract:[目的] 评价经颅磁电抑郁症(失眠)治疗仪(商品名:奥博百忧度)治疗抑郁症的有效性及安全性。[方法] 对 80例轻、中度抑郁症患者进行了随机、安慰对照、多中心4周临床试验,其中治疗组和对照组各 40例。治疗组使用经颅磁电抑郁症(失眠)治疗仪进行治疗,对照组使用经颅磁电抑郁症(失眠)治疗仪模拟治疗(音频安慰)。[结果] 临床试验研究结果表明,治疗 4 周后对照组的总显效率和总有效率分别为5.00%(2/40)和 35.00%(14/40),其 95%的可信区间分别为(0.00~11.75)和(20.22~49.78),治疗组的总显效率和总有效率分别为 65.00%(26/40)和 80.00%(32/40),其 95%的可信区间分别为(50.22~79.78)和(67.60~92.40),各中心效应有差别(P=0.0009);两组总有效率和总显效率的优效性检验 P<0.0001,且治疗组高于对照组,说明治疗组优于对照组。两组均无不良反应。[结论] 经颅磁电抑郁症(失眠)治疗仪(商品名:奥博百忧度)治疗抑郁症使用安全,疗效确切,尤其在“抑郁、有罪感、睡眠障碍、工作和兴趣、迟缓、激惹、焦虑”等主要症状方面得到明显改善。
Peer Review Status:Awaiting Review
Subjects: Biology >> Bioengineering Subjects: Biology >> Neurobiology Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics submitted time 2017-02-13
Abstract:[目的] 评价经颅磁电脑病治疗仪(商品名:奥博阿尔茨海默治疗仪)治疗轻、中度血管性痴呆(Vascular dementia,VD)的有效性及安全性。 [方法] 对80例轻、中度AD[Hachinski缺血量表评分≥7分,痴呆程度(CDR=1.0)或(CDR=2.0)]患者进行了随机、安慰对照、多中心4周临床试验,其中治疗组和对照组各40例。所有入选病例均给予正规的内科基础治疗和规范化护理,治疗组使用经颅磁电脑病治疗仪进行治疗,对照组使用模拟经颅磁电脑病治疗仪进行模拟治疗。 [结果] 治疗4周时,治疗组较对照组简易精神状态评价(MMSE)、临床痴呆程度量表( CDR) 和日常生活能力评价(ADL)分数显著改善(组间差异P依次<0.0001、0.05、0.05)。两组均无不良反应。 [结论] 经颅磁电脑病治疗仪治疗轻、中度血管性痴呆具有治疗效果,对患者的精神状态、认知行为和日常生活自理能力有较好的改善作用,且该治疗仪使用安全。
Peer Review Status:Awaiting Review
Subjects: Biology >> Bioengineering Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics submitted time 2017-02-03
Abstract:[目的] 评价经颅磁电脑病治疗仪(商品名:奥博阿尔茨海默治疗仪)治疗轻、中度阿尔茨海默病(Alzheimer disease,AD)的有效性及安全性。[方法] 对 80 例轻、中度 AD[Hachinski 缺血量表评分≤4 分,痴呆程度(CDR=1.0)或(CDR=2.0)]患者进行了随机、安慰对照、多中心8周临床试验,其中治疗组和对照组各40例。所有入选病例均给予正规的内科基础治疗和规范化护理,治疗组使用经颅磁电脑病治疗仪进行治疗,对照组使用安慰经颅磁电脑病治疗仪进行模拟治疗。[结果] 临床试验研究结果表明,治疗8周时,治疗组较对照组简易精神状态评价(MMSE)、阿尔茨海默认知评价(ADAS-Cog)和日常生活能力评价(ADL)分数显著改善(组间差异P依次<0.001、0.0001、0.05)。治疗 4周时,MMSE和 ADAS分数已有提高(组间差异 P依次<0.05、0.01)。两组均无不良反应。[结论] 根据试验统计结果,经颅磁电脑病治疗仪治疗轻、中度阿尔茨海默病具有治疗效果,对患者的精神状态、认知行为和日常生活自理能力有较好的改善作用,且该治疗仪使用安全。
Peer Review Status:Awaiting Review