Subjects: Psychology >> Developmental Psychology submitted time 2023-03-28 Cooperative journals: 《心理科学进展》
Abstract： External feedback plays a vital role in ongoing outcome monitoring and future behavioral adjustments. Previous event-related potentials (ERPs) studies have consistently associated the feedback- related negativity (FRN) component with feedback processing after decision making. Until now, several theoretical interpretations of FRN were proposed and continuously updated in the last decade, including the classical reinforcement learning theory, affective-motivational hypothesis, reward positivity (RewP) theory, Predicted response-outcome model (PRO model) and Positive affective model. Whereas different models emphasized on different aspects, no unified theory has yet been proposed to integrate all of the existing experimental evidences. Based on these literature reviews, we argued that big-sample data, multiple and complementary technologies are highly necessary in future FRN studies. Moreover, we proposed that FRN should be considered as an electrophysiological index of reward system to investigate human behaviors in complex social interaction contexts.
Subjects: Psychology >> Applied Psychology submitted time 2020-11-11
Abstract： Based on a new conceptual frame of mental health literacy (MHL), which refers to two structural dimensions including “coping with mental illness–mental health promotion” and “self–others” and three aspects including knowledge, attitude, and behavior tendency, a systematic nationwide sampling survey was conducted for the purpose of understanding the mental health literacy profile of the Chinese. This study further explored the influences of four group variables (geographical and gross domestic product (GDP) distribution, basic demographic variables, socio-economic status, and mental health background) on mental health literacy. Another aim of this study was to provide some strategies for improving mental health literacy more effectively. The Chinese Mental Health Literacy Questionnaire and Basic Background Information Questionnaire were used to assess the mental health literacy levels of the Chinese and their influencing factors. The Chinese Mental Health Literacy Questionnaire contains six sub-scales (knowledge and concepts related to mental health, knowledge and concepts related to mental illness, attitudes and behavior tendency to maintain and promote one’s mental health, attitudes and behavior tendency to cope with one's mental illness, attitudes and behavior tendency to maintain and promote the mental health of others, and attitudes and behavior tendency to cope with the mental illness of others). The questionnaires were administered to 8866 Chinese adults in nine cities (Beijing, Wuhan, Chengdu, Lishui, Kaifeng, Guilin, Zhangye, Baoding, and Linfen), which covered the well-developed, developing, and less-developed regions in China. With a balanced development considering geographical and GDP distribution, the results indicated that the mental health literacy levels among adults in different cities were low to moderate. Their influences on mental health literacy were small but significant with respect to geographical distribution, gender, age, familiarity with professional mental health service, and the frequency of contact with psychiatric patients. Regarding the structure of mental health literacy, the results of the development of national mental health literacy demonstrated that mental health maintenance and promotion literacy was better than mental illness coping literacy, and self-help literacy was better than helping others literacy. The survey found that the knowledge had relatively high individual differences, whereas attitudes and behaviors had relatively low individual differences concerning the contents of the mental health literacy. In addition, among the social influencing factors of mental health literacy this research tested, the socio-economic status was the most effective one, which showed large effect size in the knowledge and small to medium effect size in the attitudes and behavior tendency. These findings implicate that (1) improving mental health literacy is an arduous task; (2) improving the literacy of coping with mental illness should be the focus and breakthrough point of the current practice of mental health literacy promotion; (3) socio-ecological perspective should be adopted when developing a mental health literacy promotion policy; and (4) the mechanism of the attitude and behavior tendency change needs to be explored and clarified. "
Subjects: Psychology >> Medical Psychology submitted time 2019-12-27
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Subjects: Biology >> Bioengineering submitted time 2018-03-22 Cooperative journals: 《中国生物工程杂志》
Abstract：研究人类线粒体肌酸激酶uMtCK的结合位点，将其与底物肌酸和ATP结合有关的关键氨基酸进行突变，并对突变体进行酶动力学和圆二色谱数据分析，探讨这些关键氨基酸在底物识别和催化过程中的作用。结果显示，与野生酶相比，突变体Q313A和R336A的 KmCr分别提高了2.6和2.9倍，kcat下降了19%和55%；同样地，与ATP结合相关的突变体R125A和R287A分别使得KmATP升高了3.2和4.2，kcat下降了72%和38%。以上结果表明突变体R125A、R287A、Q313A和R336A影响对底物的结合，同时也降低了酶促反应的速度。利用圆二色谱比较野生酶与不同突变体的二级结构并无明显变化，但进一步的结构模拟表明底物结合位点氨基酸在与底物之间的氢键对底物的识别和酶催化过程中发挥着重要作用。
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2018-01-25 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate the effect of low-selenium diet on the liver and kidneys of rats and explore the role of macrophage polarization into M1 and M2 phenotypes in liver and kidney injuries. Methods Twenty-four rats (12 female and 12 male) were randomly divided into control group and low-selenium group and fed with normal chow (dietary selenium of 0.18 mg/kg) and low-selenium diet (dietary selenium of 0.02 mg/kg) for 109 days.After the feeding, the rats were sacrificed for HE staining to observe liver and kidney pathologies, and immunohistochemistry was performed for analyzing CCR7, CD206, CD163-positive cell numbers in the liver and kidneys. Results The rats in low-selenium group showed severer fibrosis in the liver and kidney than the control group. In either male or female rats in low-selenium group, CCR7 and CD206 expressions in the liver were comparable with those in control group, but CD163 expression was lower than that in the control group (P<0.05 for both female and male rats). In the kidney, the proximal tubule showed a slightly higher while the distal tubule showed a slightly lower CCR7 expression in low selenium group than in the control group (P>0.05). In low-selenium group, a significantly lower CD163 expression in the distal tubule and a significantly higher CD206 expression in the proximal tubule were noted as compared with the control group (P<0.05 in both female and male rats). Compared with the control rats, the male rats in low-selenium group, but not the female rats, showed a significantly lower CD163 expression in the proximal tubule of the kidney (P<0.05); the female but not the male rats in low-selenium group show a higher CD206 expression in the distal tubule (P<0.05). Conclusion Low-selenium diet can cause liver and kidney fibrosis in rats and may inhibit macrophage activationintotheM2phenotype.
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