Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-11-14 Cooperative journals: 《中国全科医学》
Abstract： Background Dietary over-restriction is common in patients with inflammatory bowel disease（IBD）and can lead to avoidant/restrictive food intake disorder（ARFID）in severe cases. Studies have shown that food literacy may influence patients' eating behavior to some extent，but whether it can directly affect ARFID in IBD patients has not been reported. Objective To understand the current status of food literacy and ARFID in patients with IBD，and analyse the correlation between the two. Methods This was a cross-sectional study，and convenience sampling method was used to select IBD patients who attended or were hospitalized in the outpatient clinics of gastroenterology and anorectal medicine in four general hospitals in Nanjing，including Jiangsu Province Hospital of Chinese Medicine（Affiliated Hospital of Nanjing University of Chinese Medicine），Nanjing Hospital of Chinese Medicine（Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine），Nanjing Drum Tower Hospital and Zhongda Hospital，Southeast University，from October 2022 to June 2023 as the study subjects. A self-made general information questionnaire，9-item Avoidance/Restriction Food Intake Disorder Screening Scale（NIAS），and Food Literacy Scale were used to investigate the study subjects，to compare the NIAS and food literacy scores of IBD patients with different characteristics，and Pearson correlation analysis was used to explore the relationship. Results A total of 438 questionnaires were distributed and 429 valid questionnaires were recovered，with a valid recovery rate of 97.95%. The NIAS score of IBD patients was（20.82±8.65），and the incidence of ARFID was 18.41%（79/429）；the food literacy score was （32.72±9.68）. Comparison of NIAS scores of patients with different disease types and disease activity showed statistically significant differences（P<0.05）. Pearson correlation analysis showed that food literacy scores，planning and management dimensions of food literacy scale and the attitude towards making scores were negatively correlated with NIAS scores in patients with IBD（P<0.05）. Conclusion The level of food literacy in IBD patients needs to be improved. ARFID was common（18.41%），and food literacy was negatively associated with ARFID. Clinical medical staff should regularly evaluate patients' food literacy，monitor their eating behavior，and develop precise health education intervention paths to improve the level of food literacy，and reduce the incidence of ARFID.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-05-05 Cooperative journals: 《中国全科医学》
Abstract： Background Intellectual activities such as reading and playing puzzle games can slow the decline of cognitive function in the elderly，but the effects of specific types of such activities on cognitive function and cognitive domains need to be further studied. Objective To explore the influence of common types of intellectual activities on cognitive function and cognitive domains of the elderly in the community. Methods From May to August 2022，stratified convenience sampling was used to select elderly people from four communities in Nanjing，Changzhou，Nantong and Xuzhou of Jiangsu Province. A face-to-face survey was conducted with a general information questionnaire and the Montreal Cognitive Assessment （MoCA） to collect data regarding sociodemographics，frequency and types of intellectual activities，and cognitive function. Stepwise multiple regression analysis was used to explore the relationship between intellectual activities and different cognitive domains. Results In total，782 cases attended the survey，and 758 of them（96.93%） who completed it were included for analysis，including123 from Nanjing，197 from Changzhou，240 from Nantong，and 198 from Xuzhou. Older people performing intellectual activities once，twice or more per week had higher total MoCA score than those performing less than one time per week （P<0.05）. The total MoCA score of those doing two or more types of intellectual activities was higher than that of those doing only one type or no intellectual activity （P<0.05）.And the total MoCA score of elderly people doing one type of intellectual activity was higher than that of those participating no intellectual activities（P<0.05）. The intellectual activities done by these older people include learning new knowledge（n=170），playing chess and cards（n=228），reading（n=228），singing（n=59），playing puzzle games（n=57），helping grand children with their homework（n=42），painting（n=16），playing a musical instrument（n=47），and practicing calligraphy（n=30）.Stepwise multiple linear regression analysis showed that learning new knowledge，reading，helping grand children with their homework，playing puzzle games and playing musical instruments were associated with cognitive function （P<0.05）. Learning new knowledge （B=0.250），reading （B=0.590），playing puzzle games （B=0.585），helping grand children with their homework （B=0.711），and playing musical instruments （B=0.643） were the influencing factors of Visuospatial/Executive （P<0.05）. Learning new knowledge （B=0.219） was an influencing factor of Abstraction and Delayed recall/Memory （B=0.727） （P<0.05）. Reading （B=0.095，0.207，0.290，0.241，0.377） was a factor affecting Naming （B=0.095），Attention （B=0.207），Language （B=0.290），Abstraction （B=0.241），and Delayed recall/Memory （B=0.377） （P<0.05）. Playing puzzle games （B=0.290） and playing musical instruments （B=0.278） were the influencing factors of Language （P<0.05）. Among various types of activities，reading was included in a total of seven regression equations，with a standardized regression coefficient of 0.225 for its impact on the total score of MoCA，which was higher than that of the other types. Conclusion Intellectual activities such as reading，learning new knowledge，playing puzzle games，helping grand children with their homework and playing a musical instrument can maintain or improve the cognitive function of the elderly in the community. The effects of different types of intellectual activities on cognitive function are domain#2;specific，which has a positive significance for the prevention and intervention of cognitive function decline of the elderly.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-03-28 Cooperative journals: 《中国全科医学》
Abstract： Background There is no effective cure for Alzheimer's disease. Early identification of mild cognitive impairment（MCI） and determination of its sensitive warning indicators are current research hotspots. Objective To explore the relationship between taste recognition decline and cognitive function，and to clarify the value of taste recognition decline in early recognition of MCI. Methods From July to August 2022，30 older adults with MCI were recruited from a Nanjing community by convenience sampling method，and were compared to age-，sex-，and years of education-matched 32 healthy controls. The General Information Questionnaire，the Montreal Cognitive Assessment-Beijing Version（MoCA-Beijing），the Mini-Mental State Examination（MMSE），the Activities of Daily Living（ADL），and the Clinical Dementia Rating were used to assess demographics，cognitive function，status of activities of daily living，and severity of dementia，respectively. The taste function was examined by the whole mouth test. Correlation analysis and the receiver operating characteristic（ROC） curve were used to determine the value of taste recognition decline in early warning of MCI. Results Two groups had no significant differences in average age，gender ratio and average years of education（P>0.05），but significantly differed in the average MoCA-Beijing score and MMSE score（P<0.05）. Compared with healthy controls，MCI patients had much lower average scores in overall taste recognition，sweet taste recognition，salty taste recognition and bitter taste recognition（P<0.05）. In MCI patients，the overall taste recognition score was positively correlated with overall cognitive function，attention，orientation（r=0.433，0.540，0.392，P<0.05），salty taste recognition score was positively correlated with delayed recall ability（r=0.379，P<0.05），bitter taste recognition score was positively correlated with attention（r=0.471，P<0.05），umami taste recognition score was positively correlated with language ability（r=0.408，P<0.05）. The AUC of the total score of taste recognition ability in predicting MCI was 0.781，with 0.844 sensitivity，0.600 specificity，and an optimal cut-off value of 18.5. Conclusion Decreased abilities of sweet，salty and bitter recognition were found in MCI patients. The decreased ability of taste recognition was closely related to cognitive function. The decrease in the total score of taste recognition ability may partially predict MCI，and is a key early warning indicator of MCI.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-01-09 Cooperative journals: 《中国全科医学》
WANG Qiu-qin
Zhang Yu-tong
Xu Yu-chen
Bai Ya-mei
CHEN Hua
JIANG Rong-rong
YAN Shu-xia
WANG Qing
XU Gui-hua
Xie Ying
Qiao Chun
Yang Juan
Abstract：
Background Gua Sha is one of the most widely used traditional Chinese medicine (TCM) non-drug therapies, which is safe, effective and easy to promote and has unique advantages in the treatment of nervous system diseases. Parkinson's disease (PD), one of the most common neurodegenerative diseases, has become a global medical problem due to the obvious side effects of drug treatment and the reduced efficacy of long-term use. Objective To explore the clinical effect of Gua Sha on PD. Methods 32 patients with primary PD in the early and middle stages were selected by purposive sampling from March 2021 to September 2021 in an outpatient clinic of Nanjing Hospital of Chinese medicine and Jiangsu Province Hospital, and were divided into observation group (16 cases) and control group (16 cases). The observation group was treated with Gua Sha combined with oral western medicine, while the control group was treated with oral western medicine alone. After 3 months of treatment and 1 month of follow-up, the scores of the third part of the unified Parkinson's disease rating scale (MDS-UPDRS Ⅲ), the non motor symptom score (NMSS) and the overall efficacy were observed. The contents of serum interleukin IL-1β and NF- κB were observed after 3 months of treatment, and the difference between the two groups was compared. Results After 3 months of treatment, the scores of MDS-UPDRS Ⅲ and NMSS in both groups were lower than those before treatment (all P<0.0001), and the scores in the observation group were lower than those in the control group (all P<0.01); The contents of serum IL-1β and NF- κB of two groups were lower than that before treatment (all P<0.05), and the contents of the observation group were lower than that in the control group (all P<0.05); The total effective rate in the observation group was 87.50% (12 of the 14 effective cases were effective and clinically controlled, accounting for 85.71%), and the total effective rate of the control group was 62.50% (0 of the 10 effective cases were effective and clinically controlled). The difference of the curative effect between the two groups was statistically significant (P<0.001). After 1-month follow-up, the scores of MDS-UPDRS Ⅲ and NMSS in both groups were lower than those before treatment (all P<0.0001), and those in the observation group were lower than the control group (all P<0.05); The total effective rate of the two groups was 87.50%. 12 cases of the 14 effective cases in the observation group were significantly effective and clinically controlled, accounting for 85.71%. The number of markedly effective and clinically controlled cases in the control group was 0. The difference between the two groups was statistically significant (P<0.01). Compared with 3 months of treatment, the MDS-UPDRS Ⅲ score of the control group decreased at 1-month follow-up (P<0.05), while the score change in the observation group was not statistically significant (P>0.05); The NMSS score of the patients in the observation group increased (P<0.05), but there was no significant difference in the change of the score in the control group (P>0.05). Conclusions Gua Sha is safe and feasible for the treatment of primary PD in the early and middle stages, which can improve some motor dysfunction of PD patients, reduce non motor symptoms, and significantly improve the clinical efficacy. Its long-term efficacy needs to be further explored by large sample and multi center research.
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc. submitted time 2022-11-16 Cooperative journals: 《中国全科医学》
Abstract：
Background Pain is one of the common non-motor symptoms in patients with Parkinson's disease (PD), and has a serious impact on the quality of life of patients. Currently, scholars have discussed the factors influencing the occurrence of pain in PD patients, but there are some differences in research results. Objective To systematically evaluate the influencing factors of pain in PD patients. Method Study on the influencing factors of pain in PD patients were searched in databases including CNKI, Wanfang, VIP, CBM, Web Of Science, PubMed, MEDLINE, EmBase and The Cochrane Library from inception to April 2022. Two researchers independently screened the literature and extracted relevant data. The risk of bias was assessed using the AHRQ scale and the Newcastle-Ottawa Scale (NOS) for cross-sectional studies and case-control studies. Descriptive analysis was conducted on all the influencing factors involved, and meta-analysis was conducted on the common influencing factors by RevMan5.3 software. Result A total of 16 studies were included, with a total sample size of 2855 cases, involving 24 influencing factors. Descriptive analysis showed that there were 2 protective factors and 22 risk factors, and meta-analysis showed that: Gender [OR=3.73, 95% (1.75,7.96), P=0.0007], course of disease [OR=1.35, 95% (1.15,1.60), P=0.0003], depressive mood [OR=1.14, 95% (1.07,1.22), P < 0.0001], UPDRSⅢ score [OR=1.07, 95% (1.03,1.11), P=0.0002], Hoehn⁃Yahr grading [OR=2.28, 95% (1.28,4.04), P=0.005], NMSS score [OR=1.68, 95% (1.46,1.93), P < 0.00001) were the influencing factors of PD pain. GRADE analysis showed moderate quality evidence are gender, NMSS score, low quality evidence are duration of illness, depressed mood and UPDRS III score, very low quality evidence is Hoehn⁃Yahr classification. Conclusion Normal cognitive function and good mental state are protective factors for PD pain, female. Long course of disease, depressive mood, motor disorder, high H-Y rating, and severity of other non-motor symptoms (sleep disturbance, fatigue) are risk factors for PD pain. Larger samples and high-quality studies are needed for further validation in the future.
Hits
Hits
Downloads
Comment