Subjects: Biology >> Biochemistry Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2021-06-25
Abstract： "
Peer Review Status:
Awaiting Review
Subjects: Biology >> Biochemistry submitted time 2021-04-08
Abstract： "
Peer Review Status:Awaiting Review
Subjects: Biology >> Biochemistry submitted time 2020-02-28
Abstract： 肺癌作为一种严重威胁人类生命健康的疾病，尽管治疗方法种类较多，但如何把握治疗时机，为患者确定最有效的治疗用药仍然是一个难题。尿液蛋白质组可以敏感的反映机体的生理变化，有希望反映药物治疗后机体的病理或生理变化。为了研究晚期肺癌患者使用不同的药物进行治疗时其尿液蛋白质组的变化情况，通过收集晚期肺癌患者治疗前后的不同时间的尿液样本，使用液相色谱联用质谱（LC-MS / MS）来检测其尿蛋白组的变化。比较结果发现，当不同的患者使用不同药物治疗后，差异蛋白的变化各不相同，其差异蛋白反映的生物学过程变化和患者的临床表现变化较为一致。这项研究结果表明，（1）能够通过尿蛋白的变化反映不同药物治疗后患者的病理生理变化；（2）当不同患者使用相同药物治疗后，尿蛋白的变化能够反映出患者体内不同的病理生理变化，且和患者的临床病情评估结果较为一致。这些发现有可能为辅助临床治疗提供重要信息。
Peer Review Status:Awaiting Review
Subjects: Library Science，Information Science >> Information Science submitted time 2017-10-11 Cooperative journals: 《数据分析与知识发现》
Abstract： [Objective] This paper establishes the BA network model of public opinion transfer process, regarding “Bandwagon Effect” and “Threshold Effect” as a starting point and according to the special inspection of public opinion. [Methods] At the same time, collect the real online data of public opinion transfer network. This paper uses the link prediction method to predict the unknown links of public opinion nodes which will appear in the forthcoming transfer process of both simulation BA network data and real public opinion data. [Resualts] The analysis results show that among many similarity indices algorithms LP link prediction algorithm can get the best prediction. It means that LP link prediction algorithm is suitable for the link prediction in such public opinion delivery network. [Limitations] There is no improvement of link predict similarity index. [Conclutions] From the point of data view, this paper proposes an effective prediction method of public opinion trends analysis to provide the theoretical support for the network of public opinion control.
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