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Your conditions: 张琳
  • The Method of Developing Agricultural Price Index

    submitted time 2024-04-03 Cooperative journals: 《农业图书情报学报》

    Abstract: [Purpose/Significance] China is a major agricultural country, and the stability of agricultural product prices directly determines the development of China's economy. Developing an agricultural product price index is of great significance for establishing a sound agricultural product price index system, providing participants with a clear understanding of the development status of the agricultural product market, and improving levels for market monitoring and early warning. [Method/Process] Based on the current research results on agricultural product prices and price indices, this study explores the principles of constructing agricultural product price indices, the framework of agricultural product price index system, index classification and grading, calculation models, and weight determination methods, in order to develop a set of agricultural product price index construction methods that are in line with the operational characteristics of agricultural products in the current wholesale market. Based on statistical data and industry research data, an empirical study was conducted on the construction of agricultural product price indices. The five major categories of agricultural product price indices, sub-categories of agricultural product price indices, large variety of agricultural product price indices, and single variety of agricultural product price indices are weighted based on the market volume of each variety of agricultural product during the reporting period of the wholesale market, using the Pap index as the principle, and given weights based on the market volume during the reporting period. The weight of the overall agricultural product price index has been optimized and adjusted, and the model has been constructed using the basis principle of the Laplace index. The weight of major categories of agricultural products such as meat, poultry, eggs, aquatic products, grain and oil, fresh fruits and vegetables is based on per capita agricultural product expenditure data from the Beijing Municipal Bureau of Statistics, while the weight of major categories of agricultural products is based on research data from the Beijing agricultural industry, avoiding the problem of imbalanced weight. [Results/Conclusions] The empirical results indicate that the framework and classification of the agricultural product price index system are reasonable, and the index calculation model and weight determination method are scientific and feasible. This not only enriches and improves the theory and method of constructing the agricultural product price index system, but also provides useful reference for the construction of other circulation chain price indexes of agricultural products, to develop the Beijing agricultural product wholesale price series index. It also plays a positive role in market monitoring and early warning of the operation of the Beijing agricultural product market, enhancing the influence of agricultural product brands, and implementing agricultural insurance.

  • The Internationalization Features of Research Topics in International Journal Articles: A Case Study in the Field of Education in China

    Subjects: Digital Publishing >> Internet Journals submitted time 2024-02-23

    Abstract: [Purposes] This study aims to achieve a multidimensional measurement and diverse categorization of the internationalization features pertaining to the research topics of international journal articles.
    [Methods] Taking the field of education in China as an example, we compared the distribution of research topics in domestic and international journal articles to reveal the differences between them. Analyzing from four dimensions – research objects, leading countries, citation impact, and audience diversity – we dissected the internationalization features of research topics in international journal articles. We constructed the TPUR thematic classification framework to categorize research topics in international journal articles into different types to summarize relevant patterns.
    [Findings] The publication of international articles in the field of education in China presents a dual perspective of China focusing on international issues and the international community focusing on China. There are differences in the focal points and impact of articles led by China and other countries. In comparison, theoretical research topics dedicated to addressing international common issues and practical research topics focusing on China’s local issues exhibit more distinct internationalization features.
    [Conclusions] Researchers need to appropriately grasp topics of interest in international academia and choose suitable channels for publication. Research management departments should establish a rational evaluation framework to guide scholars in selecting appropriate publication channels.

  • Research on Scientific Collaboration Pattern Between Mainland China and the USA Under Public Health Emergencies

    Subjects: Library Science,Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》

    Abstract: [Purpose/significance] Understanding the pattern of scientific collaboration between Mainland China and the USA-the world's leading producers of scientific publications, could be beneficial to decision-makers in research and health policy in creating and adjusting anti-epidemic strategies.[Method/process] Taking publications related to SARS and COVID-19 as research objects, this study explored the collaboration patterns of the Mainland China and the USA from the perspectives of research effort, collaboration strength, collaboration network and major fields on the basis of classification of collaboration types and improvement of Salton's index.[Result/conclusion] Both the Mainland China and the USA are the main contributors to the research on SARS and COVID-19, while the attention of the Chinese scholars to relevant research tends to change with the situation of the epidemics. Although Mainland China and the USA were the closest partners for each other in SARS and COVID-19 research, the collaboration strength between the two countries is obviously lower in COVID-19 research than that of SARS research. The USA is at the heart of both SARS and COVID-19 collaborative networks, while Mainland China's position is significantly lower. As for the research fields, Mainland China and the USA have different emphasis on the discipline distributions.

  • New Media Operation and Evaluation of “Double First Class” University Library——An Empirical Study on WeChat Reading Promotion Based on WCI

    Subjects: Library Science,Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》

    Abstract: [Purpose/significance] This paper evaluates the effect of reading promotion by university libraries using Wechat Public Number Platform under the new style environment, to reflect the influence of university libraries' Wechat marketing and communication comprehensively.[Method/process] Using WCI statistical analysis method in network metrology, 36 representative double first-class A universities in China were selected as research objects, and a new media operation performance evaluation model of university libraries was constructed. The current situation and existing problems were analyzed according to the ranking results of comprehensive influence.[Result/conclusion] Based on the analysis results, some countermeasures and suggestions are put forward, such as strengthening publicity and promotion, creating excellent content and providing personalized service, strengthening interaction function and multi-element integration,which can provide reference for the comprehensive improvement of the operation ability of new media in university libraries.

  • Technology Convergence: Connotation, Status, Measurement, and the Relationship with Interdisciplinary Science

    Subjects: Library Science,Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》

    Abstract: [Purpose/significance] The intersection and infiltration between disciplines and the convergence and integration of technologies are essential forces to promote the development of modern science and technology. By clarifying the connotation of technology convergence, this paper explores its research progress and measuring indicators, so as to provide a reference for understanding the knowledge structure of technology convergence and related research. [Method/process] We firstly employed the literature survey and bibliometrics methods to analyze the connotation of technology convergence and technology fusion. Then, we visualized the distribution of discipline and theme for technological convergence research and summarized the measurement indicators from the perspective of diversity and cohesion. Finally, we further clarified the similarities and differences between technology convergence and interdisciplinary research. [Result/conclusion] Technology convergence and technology fusion have the same connotation in many cases, and the subtle differences between them are reflected in the convergence patterns. Measuring the degree of the technology convergence includes two perspectives: 1) diversity scope: introducing the three dimensions of variety, balance, and disparity; 2) cohesion scope: concerning the network attribute of technology fields. From the first-order and second-order theme, the research activities of technology convergence and interdisciplinary are similar. Interdisciplinary indicators of the same perspective and dimension also provide a reference for measuring the degree of technology convergence, diversity and measuring the convergence relationship between different technologies.

  • A Quantitative Study on the Dynamic Relationship Between Scientific Research and Health Needs:Taking Neurological Diseases as an Example

    Subjects: Library Science,Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》

    Abstract: [Purpose/Significance] The advancement of science and technology plays a vital role in safeguarding human life security and enhancing human well-being. Quantitative research on the dynamic relationship between scientific research and health needs could provide beneficial references for layout and resource allocation of scientific research.[Method/Process] On the basis of construction of a quantitative analysis framework of the relationship between scientific research and health needs, this paper took one of the world's major disability and mortality causes, namely neurological diseases, as a case study and used scientific academic publications, multiple indicators of disease burden (disability-adjusted life years, number of fatalities, research-dependent fraction of global burden of disease) and the Human Development Index (HDI) from 2000 to 2019 to explore the matching, correlation, and regression relationships between the burden of neurological diseases and scientific research outputs.[Result/Conclusion] The results show that the burden of neurological diseases and academic outputs have been increasing globally from 2000 to 2019. In general, the scientific community has given more than adequate attention to such diseases, but some of them (e.g., migraine) have been relatively poorly studied. From the perspective of countries at different HDI levels, the burden of neurological diseases is mainly concentrated in very-high level countries, and such countries are also the main contributors of relevant research. In terms of specific diseases, very-high level countries have paid less scientific attention on diseases (e.g., epilepsy) with relatively high burden in low- and medium-level countries. The regression analysis show that increase of disease burden had a positive impact on academic outputs. Further, the number of academic outputs is affected greater by the number of deaths in comparison to the disability-adjusted life years. In addition, the existing limitations of an innovative indicator "research-dependent fraction of global burden of disease" are also demonstrated by this paper, and some related suggestions are put forward based on the data results.

  • Science of Team Science (SciTS): Connotations, Progress and Prospects

    Subjects: Library Science,Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》

    Abstract: [Purpose/significance] Nowadays, team collaboration is considered one of the effective ways to solve the complex scientific and social challenges. By clarifying the related concepts of team and team science, this paper systematically sorts out the development process and status of the emerging interdisciplinary field of SciTS. This paper aims to deepen the related researchers' understanding of the SciTS.[Method/process] Employing the methods of bibliometrics, systematic review and knowledge graph, based on clarifying the concepts and connotations of the team and team science, this paper reviewed the development and evolution of SciTS, summarized the current research progress in SciTS from three aspects of research methods, research tools and research contents, and then discussed the possible future development directions.[Result/conclusion] SciTS, an emerging interdisciplinary field, integrates various quantitative and qualitative research methods and has made significant progress in four areas:theories and models of team science, characteristics and operation of team, organization and development of team, and measurement and evaluation of team. In the future, the potential quantitative research directions in this area can be summarized as the following four aspects:1) focusing on the collaboration process and results of research teams and identifying and quantifying the influencing factors of team effectiveness; 2) revealing the characteristics of team cooperation in different disciplines and exploring the scientific quantitative evaluation methods of the team; 3) associating the research results and discoveries in the interdisciplinary field and exploring the best team cooperation mode; 4) introducing theories and methods of scientometrics and deepening the understanding of the development law of team science.

  • A Comparative Study of Three Extracurricular Reading Groups on the Reading Behavior Intervention of Primary School Students

    Subjects: Library Science,Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》

    Abstract: [Purpose/significance] This paper explores the intervention forms and effects of three extracurricular reading groups of "literature circle", "reading club" and "dialogic reading", and the requirements for reading service talents, so as to provide evidence for selecting different reading intervention forms and cultivating reading service talents. [Method/process] The third grade pupils in the same class were evenly assigned to 4 extracurricular reading groups with different intervention levels, and four-week reading intervention experiment was carried out. Data was obtained by questionnaire survey, interview and reading measurement method. [Result/conclusion] This paper finds:①Clarifying roles and responsibilities before reading will promote thinking in reading and active communication after reading. Too much guidance will restrain communication, but autonomy will promote communication to improve the reading will and reading ability.②Each of the 3 extracurricular reading groups has its own advantages, and free reading without intervention also has a positive effect. ③Extracurricular reading groups have comprehensive requirements for reading service librarians, it is suggested to strengthen the cultivating of comprehensive quality and reading guidance theory of reading service talents, and to strengthen practice in classroom.

  • 睾酮素与反社会倾向未成年犯的攻击行为:敌意注意偏向的中介和皮质醇的调节作用

    Subjects: Psychology >> Social Psychology submitted time 2023-03-27 Cooperative journals: 《心理学报》

    Abstract: Juvenile crime, as an important factor of public security, has extensively concerned the whole society. Although juvenile offenders with antisocial tendency exhibit unique behavior patterns and development characteristics, few studies have investigated the potential mechanism of aggressive behaviors in juvenile offenders. Based on the dual-hormone hypothesis and social information processing theory, It is plausible to argue that biological hormones and the social information processing process related to hostile might play an fundamental role in shaping aggressive behaviors of juvenile offenders. Therefore, the present study proposes a moderated mediating model and examined the prediction of testosterone for aggressive behaviors in juvenile offenders that is mediated by hostile attention bias and moderated cortisol. Drawing on both biological hormone and social cognition perspectives, the present study attempts to answer the questions of “how” testosterone affects aggressive behavior and “when” the effect will be present, which provides implications for further developing interventions against aggressive behaviors in juvenile offenders with antisocial tendency. This study included 84 juvenile offenders (average age: 17.55, standard deviations: 0.52) as participants. Their aggressive behavior was measured using the Chinese version of the Buss-Perry Attack Scale (AQCV). Enzyme-Linked Immunosorbent Assay (ELISA) was utilized to measure the salivary testosterone and cortisol levels of the participants. Moreover, the participants' attention biases toward hostile aggressive phrases and hostile facial expressions were evaluated using an adopted Stroop and the dot-probe paradigm, respectively. Both traditional and trail-level attention bias scores were calculated to reflect the participants' attention bias statically and dynamically.Results showed that (1) attention bias toward hostile stimuli (Variability, Peak TL-BSNEGATIVE) played a complete mediation role in the relationship between testosterone and aggressive behavior (i.e. variability played a complete mediation role in the prediction of AQCV total score, physical aggression subscale score, and anger subscale score. Peak TL-BSNEGATIVE played a complete mediation role in the prediction of verbal aggression subscale score by testosterone). (2) Cortisol moderated the relationship between testosterone and attention bias toward hostile stimuli. More specifically, at a high cortisol level, testosterone positively predicted individual attention avoidance (Peak TL-BSNEGATIVE) and variability, thereby reducing the aggression level. However, the mediation effect of attention bias toward hostile stimuli was not significant at a low cortisol level. Based on the dual-hormone hypothesis and social information processing theory, the present study examined a moderated mediating model in a sample of juvenile offenders with antisocial tendency using the perspectives of biological hormone and social information processing in aggressive behaviors. The present study revealed a potential development mechanism of aggressive behaviors in juvenile offenders and thus provides an empirical foundation for hormone-based interventions against aggressive behaviors in juvenile offenders. Finally, on the basis of the mediation and moderation effects of biological hormones on aggressive behavior, the present study indicates that increasing attention avoidance and the cortisol level for juvenile offenders with antisocial tendency might help reduce their aggressive violence.

  • 共情的双刃剑效应:COVID-19心理热线咨询师的继发性创伤应激和替代性创伤后成长

    Subjects: Psychology >> Social Psychology submitted time 2023-03-27 Cooperative journals: 《心理学报》

    Abstract: The novel Coronavirus Disease 2019 (COVID-19) outbreak increases public mental stress and pandemic-related trauma. Timely and comprehensive online mental health services have been deployed across China. Hotline counselors can be exposed to the stress and trauma experienced by callers indirectly. They may experience secondary traumatic stress (STS) as a result of their empathetic engagement with traumatized clients, and they may also experience vicarious posttraumatic growth (VPTG). The present study examined negative and positive change in hotline counselors concurrently and explored the mechanisms of both positive and negative outcomes. Participants were 776 counselors (81% female, average age = 42.57 ± 7.90, average years of experience = 12.44 ± 5.92) recruited from MOE-CCNU Mental Health Service Platform, the biggest official telephone-based and online psychological support platform in China during COVID-19 period. Empathy and VPTG were measured by revised Chinese versions of self-report questionnaires. STS was assessed by the corresponding subscale of the Professional Quality of Life Scale. The Chinese Meaning in Life Questionnaire was used to assess participants’ search for life meaning. Mindfulness was evaluated by Mindful Attention Awareness Scale. Latent variable structural equation modeling was applied. After controlling age, trauma cases and total cases, counselors’ empathy was positively associated with STS and VPTG. Results revealed that empathy was positively associated with STS and VPTG. Mindfulness mediated this association between empathy and STS. Search for meaning mediated the relationship between empathy and VPTG. Additionally, the association between empathy and VPTG was also mediated through other four significant mediating pathways: (a) secondary trauma stress, (b) secondary traumatic stress and search for meaning, (c) mindfulness and search for meaning, and (d) mindfulness and secondary trauma stress and search for meaning. Our findings support that empathy lead to both positive and negative outcomes among hotline counselors during COVID-19 period in China, highlighting dialectical insights into trauma workers’ experiences. When counselors engage in others’ traumatic experience, their vicarious negative emotional experience may be a pathway to growth, and search for life meaning is an important factor in that growth.

  • The double-edged-sword effect of empathy: The secondary traumatic stress and vicarious posttraumatic growth of psychological hotline counselors during the outbreak of COVID-19

    Subjects: Psychology >> Clinical and Counseling Psychology submitted time 2021-05-25

    Abstract: " The novel Coronavirus Disease 2019 (COVID-19) outbreak increases public mental stress and pandemic-related trauma. Timely and comprehensive online mental health services have been deployed across China. Hotline counselors can be exposed to the stress and trauma experienced by callers indirectly. They may experience secondary traumatic stress (STS) as a result of their empathetic engagement with traumatized clients, and they may also experience vicarious posttraumatic growth (VPTG). The present study examined negative and positive change in hotline counselors concurrently and explored the mechanisms of both positive and negative outcomes. Participants were 776 counselors (81% female, average age = 42.57 ± 7.90, average years of experience = 12.44 ± 5.92) recruited from MOE-CCNU Mental Health Service Platform, the biggest official telephone-based and online psychological support platform in China during COVID-19 period. Empathy and VPTG were measured by revised Chinese versions of self-report questionnaires. STS was assessed by the corresponding subscale of the Professional Quality of Life Scale. The Chinese Meaning in Life Questionnaire was used to assess participants’ search for life meaning. Mindfulness was evaluated by Mindful Attention Awareness Scale. Latent variable structural equation modeling was applied. After controlling age, trauma cases and total cases, counselors’ empathy was positively associated with STS and VPTG. Results revealed that empathy was positively associated with STS and VPTG. Mindfulness mediated this association between empathy and STS. Search for meaning mediated the relationship between empathy and VPTG. Additionally, the association between empathy and VPTG was also mediated through other four significant mediating pathways: (a) secondary trauma stress, (b) secondary traumatic stress and search for meaning, (c) mindfulness and search for meaning, and (d) mindfulness and secondary trauma stress and search for meaning. Our findings support that empathy lead to both positive and negative outcomes among hotline counselors during COVID-19 period in China, highlighting dialectical insights into trauma workers’ experiences. When counselors engage in others’ traumatic experience, their vicarious negative emotional experience may be a pathway to growth, and search for life meaning is an important factor in that growth. "

  • The status quo and characteristics of Chinese mental health literacy

    Subjects: Psychology >> Applied Psychology submitted time 2020-11-11

    Abstract: Based on a new conceptual frame of mental health literacy (MHL), which refers to two structural dimensions including “coping with mental illness–mental health promotion” and “self–others” and three aspects including knowledge, attitude, and behavior tendency, a systematic nationwide sampling survey was conducted for the purpose of understanding the mental health literacy profile of the Chinese. This study further explored the influences of four group variables (geographical and gross domestic product (GDP) distribution, basic demographic variables, socio-economic status, and mental health background) on mental health literacy. Another aim of this study was to provide some strategies for improving mental health literacy more effectively. The Chinese Mental Health Literacy Questionnaire and Basic Background Information Questionnaire were used to assess the mental health literacy levels of the Chinese and their influencing factors. The Chinese Mental Health Literacy Questionnaire contains six sub-scales (knowledge and concepts related to mental health, knowledge and concepts related to mental illness, attitudes and behavior tendency to maintain and promote one’s mental health, attitudes and behavior tendency to cope with one's mental illness, attitudes and behavior tendency to maintain and promote the mental health of others, and attitudes and behavior tendency to cope with the mental illness of others). The questionnaires were administered to 8866 Chinese adults in nine cities (Beijing, Wuhan, Chengdu, Lishui, Kaifeng, Guilin, Zhangye, Baoding, and Linfen), which covered the well-developed, developing, and less-developed regions in China. With a balanced development considering geographical and GDP distribution, the results indicated that the mental health literacy levels among adults in different cities were low to moderate. Their influences on mental health literacy were small but significant with respect to geographical distribution, gender, age, familiarity with professional mental health service, and the frequency of contact with psychiatric patients. Regarding the structure of mental health literacy, the results of the development of national mental health literacy demonstrated that mental health maintenance and promotion literacy was better than mental illness coping literacy, and self-help literacy was better than helping others literacy. The survey found that the knowledge had relatively high individual differences, whereas attitudes and behaviors had relatively low individual differences concerning the contents of the mental health literacy. In addition, among the social influencing factors of mental health literacy this research tested, the socio-economic status was the most effective one, which showed large effect size in the knowledge and small to medium effect size in the attitudes and behavior tendency. These findings implicate that (1) improving mental health literacy is an arduous task; (2) improving the literacy of coping with mental illness should be the focus and breakthrough point of the current practice of mental health literacy promotion; (3) socio-ecological perspective should be adopted when developing a mental health literacy promotion policy; and (4) the mechanism of the attitude and behavior tendency change needs to be explored and clarified. "

  • 基于标准置换检验的差异序列模式挖掘算法

    Subjects: Computer Science >> Integration Theory of Computer Science submitted time 2020-09-28 Cooperative journals: 《计算机应用研究》

    Abstract: To filter out the false positive patterns returned from the discriminative sequential patterns mining methods, this paper proposed a standard permutation based method called SP-DSP. This method first mined frequent sequential patterns by the GSP algorithm, then the patterns whose Growth rate are less than the threshold were eliminated. Finally, the standard permutation method was used to compute the p-values of tested patterns. As a result, the number of false positive patterns can be controlled under the multiple hypothesis testing measures. The experiments showed that the SP-DSP algorithm can alleviate a lot of false positive patterns and retain as many true patterns as possible, which improves the accuracy of the downstream classification tasks.

  • 睾酮素与未成年犯的攻击行为:敌意注意偏向的中介作用和皮质醇的调节作用

    Subjects: Psychology >> Clinical and Counseling Psychology submitted time 2020-07-03

    Abstract: " "

  • 移动环境下基于情境感知的个性化影视推荐算法研究

    Subjects: Computer Science >> Integration Theory of Computer Science submitted time 2019-04-01 Cooperative journals: 《计算机应用研究》

    Abstract: Aiming at the problem of low accuracy in the use of traditional recommendation algorithm in mobile environment, a matrix factorization algorithm based on context-aware was proposed. Based on the basic matrix factorization algorithm, the algorithm performed unknown score prediction by incorporating global bias and context bias. The advantage of this algorithm is that, on the one hand, the matrix factorization was used to make the scale of the matrix much smaller than the original scoring matrix; on the other hand, the algorithm fully integrated the influence of the situational elements on the score, making the prediction score more accurate. Experiments on the LDOS-CoMoDa dataset show that the proposed algorithm outperforms the user-based collaborative filtering algorithm, the basic matrix factorization algorithm and Baseline prediction algorithm.

  • 亚麻籽油对脂多糖刺激断奶仔猪肠黏膜结构和免疫细胞的影响

    Subjects: Biology >> Zoology submitted time 2018-12-20 Cooperative journals: 《动物营养学报》

    Abstract:本试验旨在研究亚麻籽油对脂多糖(LPS)刺激断奶仔猪肠黏膜结构和免疫细胞的影响。选择24头(9.15±0.90) kg杜×长×大断奶仔猪,随机分为4组,每组6个重复,每个重复1头猪。试验采用2×2因子设计,主因子包括:1)饲粮处理(5%玉米油或5%亚麻籽油);2)免疫应激(注射生理盐水或LPS)。饲粮中添加5%玉米油或5%亚麻籽油饲喂21 d,在试验第21天,每组1/2的猪腹膜注射100 μg/kg BW的LPS,另外1/2的猪腹膜注射等量生理盐水。注射LPS或生理盐水4 h后,将仔猪麻醉屠宰,取肠道样品待测。结果表明:1)LPS刺激显著降低了空肠、回肠绒毛高度和空肠隐窝深度(P0.05);饲粮添加5%亚麻籽油有提高回肠派氏结细胞密度的趋势(P<0.10),且在LPS刺激下,显著降低空肠固有层细胞密度(P<0.05),并有增加空肠上皮间淋巴细胞数目的趋势(P<0.10)。结果提示,5%亚麻籽油在一定程度上可维护LPS刺激断奶仔猪的小肠黏膜结构和免疫功能。

  • 聚乳酸-羟基乙酸共聚物载肝细胞生长因子纳米粒的构建及生物学活性评价

    Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2018-06-15 Cooperative journals: 《南方医科大学学报》

    Abstract: Objective To explore the optimum conditions for preparing poly(lactic-co-glycolic) acid (PLGA) nanoparticles and evaluate the bioactivity of hepatocyte growth factor (HGF)-loaded PLGA nanoparticles. Methods Bovine serum albumin (BSA)-loaded PLGA nanoparticles were prepared using a double emulsion-solvent evaporation method. The preparation process of nanoparticles was optimized by orthogonal test with the particle size, encapsulation efficiency (EE), drug loading (DD), and recovery as the indexes. HGF-loaded nanoparticles were then prepared under the optimized conditions. The EE, DD and release characteristics of BSA-loaded nanoparticles and HGF-loaded nanoparticles were evaluated using a BCA kit and HGF ELISA kit. The bioactivity of HGF-loaded nanoparticles was evaluated using CCK8 proliferation assay. Results The HGF-loaded nanoparticles prepared under the optimized conditions had a uniform size with a mean diameter of 234.4�.8 nm, an EE of (77.75�.04)% and a recovery rate of (49.33�.34)%. The in vitro release curve highlighted an initial burst drug release followed by sustained release from the nanoparticles. HGF-loaded nanoparticles obviously promoted the proliferation of Hacat keratinocytes in vitro. Conclusion HGF-loaded nanoparticles prepared using double emulsion-solvent evaporation method under optimized conditions possesses a high EE with a good sustained drug release profile and a good bioactivity.