Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-03-30 Cooperative journals: 《中国全科医学》
Abstract： Background In recent years，with the aging of the population and the change of lifestyles，patients with type 2 diabetes mellitus （T2DM） have a high prevalence of malignancies，the duration of T2DM and the use of T2DM drugs may accelerate the occurrence of malignant tumor. Objective To analyze the risk of incidence and influencing factors of malignant tumors in patients with T2DM. Methods Patients with T2DM who were first treated or diagnosed at the Affiliated Hospital of Nantong University from October 1，2011 to December 31，2020 were prospectively included，with the follow-up termination date of September 30，2021. The information of tumor incidence and full cause of death of patients were obtained by matching the ID information with the linkage records of the chronic disease tumor registration system and the cause of death registration system of Nantong City. The incidence rate and standardized incidence ratio（SIR） of malignant tumors among T2DM patients were calculated separately by gender. Cox proportional hazard regression model was used to explore the effects of the duration of T2DM and drug use on the incidence of malignant tumor in T2DM patients. Results A total of 12 006 patients with T2DM were included in this study，involving 6 328 males （52.71%） and 5 678 females （47.29%）. After 56 371 personyears of observation（29 543 person-years for males and 26 824 person-years for females），601 patients with malignant tumor and 11 405 patients with T2DM alone were observed. The incidence of malignant tumor in T2DM patients was 1 093.24/100 000 in men and 1 032.51/100 000 in women，respectively. The incidences of colorectal cancer（ SIR=2.03），prostate cancer （ SIR=2.24）， pancreatic cancer（ SIR=1.75），kidney cancer（ SIR=4.25），thyroid cancer （ SIR=3.50） were higher in male T2DM patients
than general population，while the incidences of lung cancer （ SIR=0.61） and esophageal cancer （ SIR=0.22） were lower than general population. The incidences of breast cancer （ SIR=2.59），colorectal cancer （ SIR=1.57），pancreatic cancer （ SIR=2.10），endometrial cancer （ SIR=2.83），kidney cancer（ SIR=3.67），thyroid cancer（ SIR=4.00） were higher in
female T2DM patients than general population，while the incidence of esophageal cancer（ SIR=0.27） was lower than general population. Compared with T2DM patients with disease duration of 1 to <3 years，the risk of malignant tumor was increased by 91% 〔 HR=1.91， 95%CI（1.15，3.20）〕，123%〔 HR=2.23， 95%CI（1.37，3.64）〕 and 71%〔 HR=1.71， 95%CI（1.04，2.80）〕in male with disease duration <1 year，5 to <10 years and ≥ 10 years，respectively，the risk of malignant tumor was increased by 79%〔 HR=1.79， 95%CI（1.10，2.92）〕 and 99%〔 HR=1.99， 95%CI（1.24，3.19）〕 in female with T2DM duration of 5 to <10 years and ≥ 10 years，respectively. Insulin use alone increased the risk of malignant tumor by 72%〔 HR=1.72，95%CI（1.25，2.36）〕and 116%〔 HR=2.16， 95%CI（1.53，3.05）〕 in male and female，respectively. In addition，there was a significant interaction between insulin use and the duration of T2DM in male，the risk of malignant tumor was decreased by an average of 6% with the interaction over the years（ P=0.006）. Conclusion In addition to esophageal cancer in both sexes and lung cancer in male，the risk of colorectal cancer，prostate cancer，pancreatic cancer，kidney cancer，thyroid cancer，breast cancer and endometrial cancer increase by 57%-300% in patients with T2DM，and associated with the disease duration and insulin use，with the greatest risk of malignant tumor in male with disease duration of 5 to <10 years and in female with disease duration of ≥ 10 years. However，there is an antagonistic interaction between insulin use and increased duration of T2DM disease on the incidence of malignant tumor.
Subjects: Psychology >> Social Psychology Subjects: Computer Science >> Computer Application Technology submitted time 2018-03-15
Abstract： 理清“一带一路”沿线国家或地区的民心特点，并找到有效的合作交往模式，是关系到国家战略实施的重大问题。但是，由于地域辽阔、民族众多，且地缘政治、经济、文化因素（如原苏联影响、欧美国家殖民、宗教传统等）异常复杂，传统的分析方法往往难以奏效。该研究结合文化心理学和大数据分析技术，利用社交媒体Twitter数据来分析“一带一路”沿线国家或地区的自我表征特点（独立性或个人主义），并建立自我表征与社会信任（普遍信任、特殊信任）的预测模型，以探究与“一带一路”沿线国家或地区合作交往的行为模式，即：自我表征是独立，还是互依；人际关系偏好是陌生人之间的普遍信任，还是熟人间的特殊信任。结果表明，“一带一路”沿线国家或地区在自我独立性这一个人主义文化指标上存在较大的变异，且主要受欧美国家殖民历史和当地宗教传统的影响；此外，针对陌生人、外国人的普遍信任与针对家人、熟人的特殊信任，可以通过个人主义指标来预测。总之，“一带一路”沿线的文化是多样的，可以通过社交媒体产生的海量语料库快速计算其个人主义指标，并以此来建立自我表征与社会信任的预测模型。该研究为分析“一带一路”战略区域的“民心”特点、探索当地合作交往的行为模式提供了新的技术路径。
Peer Review Status:
Awaiting Review
Subjects: Other Disciplines >> Synthetic discipline submitted time 2016-11-04 Cooperative journals: 《中国科学院院刊》
Abstract：海岸带及海洋环境中的微塑料污染已经成为全球环境问题。我国已对一些典型河口、海湾、海岛周边海域及潮滩开展了微塑料污染的初步调查，积累了一些基础数据。但目前从基础理论、方法学及评估与控制技术等方面都远未达到环境监管的要求。因此，需要从建立和完善微塑料调查、监测与评估的方法学体系，厘清我国海洋微塑料的排放格局与污染分布规律，建立微塑料及其附着污染物的毒理学评价指标体系与参数库，形成海洋及海岸环境微塑料污染控制与管理技术体系等角度开展全面系统研究，解决现有的技术难点和关键科学问题，为我国海岸及海洋环境微塑料污染的监管与安全保障提供科学支撑。
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