Subjects: Psychology >> Experimental Psychology Subjects: Psychology >> Psychological Measurement submitted time 2024-03-04
Abstract： Statistical power is one of the key indicators for assessing the robustness and replicability of research results. However, the standardization and completeness of calculating and reporting statistical power in event-related potential studies still need improvement. This paper aims to provide researchers with references for calculating and reporting statistical power during the design or preregistration of research protocols at various stages of event-related potential studies by summarizing the influencing factors, methods, and application examples of statistical power in such studies.
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Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-01-09 Cooperative journals: 《中国全科医学》
Abstract：
Background Triglyceride glucose product (TyG) index is an index to evaluate insulin resistance (IR) and obesity-related metabolic diseases, but there are few studies on the correlation between this index and the high risk of cardiovascular disease (CVD) in middle-aged obese people of different genders. Objective To investigate the relationship between TyG index and the high risk of CVD in middle-aged obese people of different genders, and to evaluate its role in the prevention and treatment of CVD. Methods A total of 30,425 obese middle-aged (45-60 years old) permanent residents in Anhui Province were selected as research objects and divided into male group and female group according to different gender. Male TyG index was divided into four quartiles: T1 (7.420-8.870), T2 (8.870-9.204), T3 (9.204-9.578), T4 (9.578-11.440). The female group was divided into T1 (7.579-8.876), T2 (8.876-9.183), T3 (9.183-9.526) and T4 (9.526-11.647). χ2 test was used to analyze the detection of CVD risk in different genders. Multivariate binary Logistic regression model was established to explore the relationship between TyG index and the high risk of CVD, and Z-test was used to compare the difference in effect values between subgroups. Result The high risk of CVD was 28.4% in the male group and 26.0% in the female group. The results of multivariate binary logistic regression model showed that in male group and female group, each quartile grouping of TyG index had statistical significance (P<0.01). Compared with T1, the high risk of CVD at TyG index T4 in male group and female group [OR(95%CI)] was 1.827(1.622, 2.058) and 1.552(1.410, 1.708), respectively, and there was a statistically significant difference in the OR values between male and female groups in T4 (P<0.05). After further adjustment of total cholesterol and other indicators, the correlation between TyG index and the high risk of CVD was weakened, and the TyG index in the two groups showed statistical significance at T2, T3 and T4 (P<0.05), and with the gradual increase of TyG index level, the correlation with the high risk of CVD gradually increased. Compared with T1, in male and female groups, the TyG index of high risk of CVD in T4 group [OR(95%CI)] was 1.804(1.584, 2.055) and 1.496(1.345, 1.665), respectively. There was a statistically significant difference in the OR value between male and female groups in T4 (P<0.05). Conclusion Middle-aged obese men with a high level of TyG index are more prone to CVD risk, and the TyG index level of this group should be paid more attention to.
Subjects: Biology >> Bioengineering submitted time 2017-11-26 Cooperative journals: 《中国生物工程杂志》
Abstract：目的：基于液质联用的串联质谱技术，建立基于完整糖肽水平的抗体药糖型定性定量分析方法，并用于生物仿制药糖型研究。方法：基于液相色谱质谱技术，从完整糖肽水平对糖型进行定性定量分析，同时与传统超高效液相荧光检测（Ultra Performance Liquid Chromatography_Fluorescence detection，UPLC-FLR）结果比较，获得最优分析策略，并用于曲妥珠单抗仿制药批次间糖型定性定量分析。结果：UPLC-FLR方法定量分析了贝伐单抗7种糖型；液质联用方法定量19种糖型；经亲水相互作用色谱（Hydrophilic interaction chromatography，HILIC）富集后，定量22种糖型。曲妥珠单抗仿制药批次间糖型定量结果显示良好的一致性。结论：基于液质联用的方法，具有速度快、灵敏度高、检测糖型种类多等优势，有望作为一种稳定的抗体药物糖蛋白位点特异性定量分析策略。
Subjects: Biology >> Bioengineering submitted time 2017-11-26 Cooperative journals: 《中国生物工程杂志》
Abstract：目的：基于液质联用的串联质谱技术，建立基于完整糖肽水平的抗体药糖型定性定量分析方法，并用于生物仿制药糖型研究。方法：基于液相色谱质谱技术，从完整糖肽水平对糖型进行定性定量分析，同时与传统超高效液相荧光检测（Ultra Performance Liquid Chromatography_Fluorescence detection，UPLC-FLR）结果比较，获得最优分析策略，并用于曲妥珠单抗仿制药批次间糖型定性定量分析。结果：UPLC-FLR方法定量分析了贝伐单抗7种糖型；液质联用方法定量19种糖型；经亲水相互作用色谱（Hydrophilic interaction chromatography，HILIC）富集后，定量22种糖型。曲妥珠单抗仿制药批次间糖型定量结果显示良好的一致性。结论：基于液质联用的方法，具有速度快、灵敏度高、检测糖型种类多等优势，有望作为一种稳定的抗体药物糖蛋白位点特异性定量分析策略。
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