Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2024-03-26 Cooperative journals: 《中国全科医学》
Abstract： Background The level and quality of diagnosis and treatment of Helicobacter pylori（Hp）infections in Shanghai's community health service Institutions is unclear，and there is a lack of systematic evaluation and monitoring. Objective To understand the current status of diagnosis，treatment and management of Helicobacter pylori（Hp）infection in community health centers in Shanghai，to evaluate the quality of diagnosis and treatment，and to explore the problems and improvement measures. Method A questionnaire was distributed to a total of 249 community health centers in 16 administrative districts of Shanghai and 3 875 general practitioners（GPs）working in the community health centers from May to June 2022 to investigate the standardization of prescriptions for the eradication of Hp infections in the community health centers，the detection of Hp infections，the provision of drugs for the eradication of Hp infections，the management of Hp infections，the difficulties of Hp infections in the treatment of Hp infections，as well as the knowledge of community-based GPs on the diagnosis and treatment of Hp infections. Result The result of the prescription eradication program for Hp infection in primary health care facilities in Shanghai was only 32.0 percent correct. The proportion of health service centers with the ability to conduct Hp infection testing in primary healthcare institutions in Shanghai is high，nearly 80%. Most of the community health service centers were able to equip the basic medicines needed for the eradication of Hp，but the rate of bismuth equipment was low，54.6%. The rate of Hp diagnosis and treatment standard supervision was 80.0%. The demand for the training of standardized diagnosis and treatment of Hp infections was high，accounting for 66.7%. The main difficulties in Hp infection diagnosis and treatment were incomplete drug provision，insufficient doctor's diagnosis and treatment ability and insufficient equipment. Community general practitioners do not have enough basic knowledge about the diagnosis and treatment of Hp infection. Conclusion The capacity to conduct Hp testing needs to be further strengthened in primary care organizations in Shanghai，especially in remote community health service centers，including the purchase of more Hp-related testing equipment and reagents，and the completion of related medications needed for the eradication of Hp. In addition，it is necessary to further strengthen the standardized diagnosis and treatment training of Hp infection for community health centers，improve the diagnosis and treatment ability of general practitioners on Hp infection，and at the same time，strengthen the supervision of Hp diagnosis and treatment standardization，so as to further improve the diagnosis and treatment ability of community general practitioners on Hp infection.
Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2024-03-04 Cooperative journals: 《中国全科医学》
Abstract： Background Surgery is one of the main means of treating colorectal cancer. However，patients with colorectal cancer need to face many physical and psychological problems after surgery，which seriously affects patients’ treatment outcomes and quality of life，so how to carry out effective postoperative management is extremely important. Objective To investigate the effectiveness of an integrated hospital-community-patient chronic disease management pathway intervention for postoperative colorectal cancer patients. Methods Based on different postoperative interventions，colorectal cancer patients were divided into a control group （n=40） and a co-management group （n=36），with the control group implementing conventional postoperative interventions and the co-management group following a constructed integrated chronic disease pathway for co-management. Changes in laboratory indices，recurrent metastasis，death，postoperative complications，quality of life，and anxiety were compared between the two groups before and after surgery. Results At 3 and 6 months postoperatively，patients in the co-management group had lower carcinoembryonic antigen levels than patients in the control group （1.4 ng/mL vs.3.2 ng/mL，χ2 =-4.653，P<0.001；2.6 ng/mL vs. 3.8 ng/mL，χ2 =-3.634，P<0.001）. The incidence of recurrent metastases was not significantly different from that of the control group at 3 months postoperatively （P>0.05），while at 6 months postoperatively，the incidence of recurrent metastases was lower in the co-management group than in the control group （5.6% vs. 22.5%，χ2 =4.395，P=0.036）；in addition，the incidence of complications was lower in the co-management group than in the control group at both 3 and 6 months postoperatively（0 vs. 16.2%，χ2 =3.981，P=0.046；5.6% vs. 25.0%，χ2 =5.388，P=0.020）.However，the difference in mortality at 6 months postoperatively between the two groups was not significant （2.8% vs. 7.5%，χ2 =0.165，P=0.685）. In quality of life scores at 6 months and 1 year postoperatively，the co-management group was higher than control patients ［（48.74±2.16）points vs. （44.73±3.41）points，t=-5.922，P<0.001；（42.03±1.94）points vs.（36.98±4.65）points，t=-5.952，P<0.001］，and the anxiety scores were lower in the co-management group than in the control patients ［（60.12±6.23）points vs.（63.56±4.72）points，t=2.650，P=0.010；（66.49±5.67）points vs.（72.41±5.25）points，t=4.600，P<0.001］. Conclusion The integrated hospital-community-patient chronic disease management pathway can reduce postoperative complications，decrease recurrence and metastasis of colorectal cancer，improve quality of life，and improve anxiety symptoms，and is of great value to the prognosis of postoperative colorectal cancer patients.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-01-31 Cooperative journals: 《中国全科医学》
Abstract： With the continuous deepening of the reform of the primary care and health system，the standardization of primary health information has received more and more attention. As an important part of the construction of primary health information，primary care diagnostic coding plays an important role in improving the efficiency of primary care management，promoting the quality control of primary care，and effectively collecting primary care data. However，China has used the disease classification of general hospitals as the primary care diagnostic code for a long time，which not only leads to the chaotic state of non-standard and non-standardized primary care diagnosis，but also causes loss and error in the data collection，record and analysis in primary care. By summarizing the historical development of primary care diagnostic coding at home and abroad，this paper points out five main problems faced by China 's primary care diagnostic coding：the lack of attention to primary care diagnostic coding，the lack of unified primary care diagnostic coding leads to the limited development of primary care function and quality in China，the disagreements about which international primary care classifications match the primary care diagnostic codes in China，the various challenges faced by the localization of primary care diagnostic coding，and the lack of talents and tools to evaluate and optimize primary care diagnostic coding in China. On this basis，combined with the development process of foreign primary care diagnostic coding，it is proposed that all parties in China should pay attention to the development of primary care diagnostic coding. While further promoting the construction of primary care information in line with international standards，the national unified primary care diagnostic coding standard should be formulated based on the current trial ICD-11 and ICPC-3 classification as soon as possible，and the sound training system for primary care diagnostic coding talents should be established to further implement and optimize primary care diagnostic coding in China.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-01-31 Cooperative journals: 《中国全科医学》
Abstract： The professional capacity and infrastructure of general practitioners in grass-roots medical and health institutions in China are relatively weak，and the energy of specialists in general hospitals is limited and resources are abundant， so we will further integrate the medical resources of community health institutions and general hospitals and strengthen the cooperation between general practitioners and specialists. In order to better protect the quality of medical care and promote the health of patients. This paper systematically sorts out the typical practices and experiences of the construction of outpatient clinics of combination of general practice and specialty，and takes the source，connotation，construction path and construction path of the concept of full-specialty combination of outpatient clinics Development effectiveness，existing problems and strategic recommendations are elaborated. Point out the challenges that may be faced in the construction of outpatient clinics of combination of general practice and specialty management model. In addition，in view of the innovative practices of each region，five aspects of suggestions are put forward in combination with existing problems: Improve the rules and regulations for the construction of outpatient clinics of combination of general practice and specialty，coordinate and unify the outpatient path of outpatient clinics of combination of general practice and specialty，pay attention to the protection of outpatient clinics of combination of general practice and specialty teams，clarify the population of outpatient clinics of combination of general practice and specialtyservices，and improve the health evaluation system for the outcomes of outpatient clinics of combination of general practice and specialty.In order to provide reference for the country to carry out the construction of outpatient clinics of combination of general practice and specialty in depth.
Subjects: Psychology >> Other Disciplines of Psychology submitted time 2023-06-15
Abstract： Precision functional magnetic resonance imaging (pfMRI) refers to a data acquisition strategy that collects large amounts of fMRI data in single individuals. Compared with traditional fMRI research, which collects a small amount of data for each participant and then reveals the underlying brain mechanisms of cognitive process or the shared brain function features of a specific population through the group average, the advantage of this method is that it can reveal the individual brain features, so it has been increasingly recognized and applied by researchers. So far, numerous studies have utilized this approach to systematically reveal the characteristics of individual brain functional network organization, which mainly include the following six aspects: individual differences in functional network organization, individual identification, functional localization of local brain regions, identification of individual network hubs, development and plasticity of the individual functional network, and clinical application. These research findings provide significant insights for future studies in the field of brain science. Future research should focus on exploring the relationship between the features of individual functional networks and behavioral performance, reduce the scanning time demand of the pfMRI through the improvement of data analysis and imaging technology, and attempt to introduce this method into task-state fMRI and multimodal research.
Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2023-04-19 Cooperative journals: 《中国全科医学》
Abstract： Background Coordinated regional health development aims to optimize resource allocation by constructing a well-structured and functional regional collaborative system to provide continuous medical services，and to leverage the unique features and strengths of medical centers and community health centers within a region via fully integrating resources and sharing information. However，current available systems for assessing coordinated regional health development mainly focus on outcomes，which are relatively non-diversified and unsystematic，thus further research is required to fill this gap. Objective We aimed to construct an evaluation system for coordinated regional health development，to provide scientific evidence for evaluating the coordinated development capacities of regions. Methods We collected essential factors related to coordinated regional health development through a literature review and semi-structured interviews，and used them to construct a draft version of the Coordinated Regional Health Development Assessment System（CRHDAS）. Then we selected 19 experts who were familiar with coordinated regional health development（engaging in general medicine，medical education，administrative management，and public health management） from Shanghai using stratified sampling to attend two rounds of online combined with offline Delphi questionnaire surveys from December 2020 to March 2021 to determine the weights of the indicators and test the logical consistency of the weights of indicators at each level using Analytic Hierarchy Process. After that，we established the final version of CRHDAS. Results The effective response rate and authoritative coefficient were 95.0% and 0.87，respectively，for the first round of survey，and were 100.0% and 0.92，respectively，for the second round of survey. The CRHDAS consists of four first-level indicators（with corresponding weights of 0.387，0.296，0.187 and 0.130），12 second-level indicators，and 31 third-level indicators. The consistency ratios for the weights of three levels of indicators are <0.100. Conclusion The CRHDAS is of high-level scientificity and practicality，which can help identify problems and deficiencies of the collaboration mode between community health centers，providing a theoretical and practical basis for guiding coordinated regional health practice in the future.
Subjects: Psychology >> Developmental Psychology submitted time 2023-03-28 Cooperative journals: 《心理科学进展》
Abstract： Statistical learning (SL), which was first addressed in the seminal study on speech segmentation of infants by Saffran et al. (1996), is a process of detecting the statistical regularities such as transitional probability in continuous flow of stimuli. Previous studies have proven the general existence of SL, and in recent years close attention has been placed on its specificity and its impact on other cognitive activities, especially revealing the cognitive neural mechanisms of SL and its interaction with language by exploring the process and the specificity of SL. According to the multimodal data from brain and behavior measures, future studies should seek more behavioral and neural indexes to evaluate the performance of SL, to explore the dynamic changes in neural activities of different types of SL and to construct the connection between neural correlates and behavioral performance, which will help to have an in-depth understanding of SL. Based on previous discoveries on the interaction between SL and language, future studies could determine whether SL is an effective intervention to improve language acquisition and how it works in the improvement, through exploring the effect of music SL training on second language learning of adult learners.
Subjects: Psychology >> Social Psychology submitted time 2023-03-27 Cooperative journals: 《心理学报》
Abstract： Global motion perception (GMP) is an important aspect of visual perception. Numerous studies have found that GMP of cognitively healthy elderly declines with aging and it cannot be explained by age differences in the visual system. The neural mechanism of aging on GMP remains unclear. Resting-state fMRI has been widely used to detect the internal spontaneous activity of the aging brain. Thus, whether the functional activity of brain regions related to the GMP for the elderly in the resting state is an effective indicator of their global motion sensitivity (GMS) still needs further investigation. To reveal the neural basis of GMP decline for the elderly, the relationships between the resting-state functional activities of GMP related brain areas (Regions of Interest, ROI: V1, V2, V3, and MT/V5) and individuals’ motion coherence threshold (MCT) were analyzed by using rs-fMRI technology. In this study, Random Dot Kinematogram (RDK) paradigm was used to evaluate an individual’s GMS with the MCT as the indicator. A higher threshold of the RDK task meant lower sensitivity. Meanwhile, the rs-fMRI data of 36 younger adults (M = 22.04 years old) and 31 older adults (M = 65.05 years old) were acquired using rapid echo-planar imaging (EPI) sequence from a 3T Siemens Prisma magnetic resonance scanner, with TR = 2s, TE = 30ms, Time points = 240 (young) or 246 (old). Rs-fMRI data were preprocessed and processed using SPM (http://www. fil.ion.ucl.ac.uk/spm) and DPABI (http://rfmri.org/dpabi) toolbox to obtain the functional activities of the ROIs, including ReHo, ALFF, voxel-wise FC, and ROI-wise FC. Then, the regional measures including three nodal centrality metrics (degree K, efficiency Enodal and betweenness b) and the global measures including small-world parameters (clustering coefficient Cp, characteristic path length Lp, normalized clustering coefficient γ, normalized characteristic path length λ, and small-worldness σ) and network efficiency (global efficiency Eglob and local efficiency Eloc) were calculated using GRETNA (http//www.nitrc.org/projects/gretna/) graph toolbox. To determine whether there were significant group differences in these functional properties, two-sample t-tests were performed on each metric. When significant between-group differences in any functional metrics were obtained, the Pearson correlation coefficients among these metrics and individuals’ MCT were further calculated to assess the relationship between changes in brain function and GMP aging. Results showed that 1) the ReHo values of right V3 and bilateral MT/V5 for older adults were significantly lower than that of younger adults, as well as the ALFF of bilateral MT/V5, and these functional metrics were significantly negatively correlated with individuals’ MCT; 2) The FCs between V2 and left primary motor cortex, V3 and left secondary visual cortex, MT/V5 and left premotor cortex, as well as the FCs between V1, V2, V3 and MT/V5 regions for the older adults were significantly stronger than that of younger adults, and these FCs were correlated with individuals’ MCT; 3) Older adults’ K, Enodal and b of most nodes in temporal lobe were significantly lower than younger adults, and the Enodal of the right temporal cortex were significantly negatively correlated with individuals’ MCT; 4) Older adults’ global network properties including small-world parameters (Cp, γ, Lp, λ, and σ) and network efficiency (Eglob and Eloc) were all significantly lower than younger adults’, with CP and Eloc significantly negatively correlated with their MCT.These findings suggested that the decline of GMS for the elderly was associated not only with functional changes in the dorsal visual pathway, especially in the MT/V5, but may also with functional changes in broader areas of the whole brain, which supported the theory of “dedifferentiation”.
Subjects: Psychology >> Social Psychology submitted time 2023-03-27 Cooperative journals: 《心理学报》
Abstract： Misinformation often continues to influence people’s beliefs and reasoning even after retracted—this persistence is termed the ‘continued influence effect of misinformation’ (CIEM). Both of the mental-model- updating hypothesis and the memory-retrieval-failure hypothesis attempt to explain this phenomenon. The neural substrates of CIEM are controversial, and results from different studies support different assumptions. The disputations may relate to neglection of potential contribution of inhibitory control in CIEM and of methodological differences between studies. This study aimed to investigate neural substrates and cognitive mechanism of CIEM using the functional magnetic resonance imaging (fMRI) from the view of inhibition control. Thirty-one participants (10 males) were recruited in this study. They were instructed to read brief, fictional news reports and answer three inference questions after reading while lying in a 3.0T Siemens Prisma MRI scanner. Each participant needed to read 40 reports (20 reports in their retraction versions and 20 in their control versions). Each fictional report contained six sentences and derived retraction and control versions based on whether the second sentence contained misinformation. Pseudorandom uniform temporal jitter was used for this fMRI design. Imaging data were preprocessed and processed using SPM, RESTplus and DPABI toolbox to obtain the functional activities of the ROIs and their functional connectivity. Multi-comparison tests were conducted for brain activities induced by target sentence 5 (encoding phase) and three reasoning sentences (retrieval phase) under different versions. The results showed: (1) retractions elicited less activity in the left middle temporal gyrus (BA21/22) than control during encoding phase; and retractions also elicited less activity in the left middle frontal gyrus (L_MFG, BA10) and right anterior cingulate cortex (R_ACC, BA32) than control during retrieval phase. Additionally, activation at the left dorsolateral prefrontal cortex (L_DLPFC, BA9) in the retraction condition was marginally significantly different from that in the control condition during retrieval phase. No significant activation difference was observed across conditions in others ROI. (2) A marginally significantly negative correlation was found between functional metrics (Beta) of the left MFG in retraction condition and individuals’ interference scores. (3) With regard to functional connectivity, we compared the connectivity between two seeds (left MFG and right ACC) and the rest of the brain in control versus retraction condition during retrieval phase. Results demonstrated that the right ACC showed decreased functional connectivity with the bilateral inferior occipital gyrus (IOG) under retraction condition when compared to control condition. The left MFG showed similar decreased connectivity with the bilateral IOG under retraction condition when compared to control, but increased functional connectivity with right precentral gyrus under retraction condition when compared to control. The results suggest that the CIEM be related to semantic encoding failure during information comprehension and inhibition failure of misinformation during information retrieval. The mental-model-updating hypothesis and the memory-retrieval-failure hypothesis can explain the different phase of CIEM. The findings provide more experimental evidence for neural basis of CIEM and refine corresponding theoretical accounts, and provide neurological clues for further exploration of ways to reduce the negative impact of CIEM in the future.
Subjects: Psychology >> Cognitive Psychology Subjects: Psychology >> Developmental Psychology submitted time 2020-08-22
Abstract： " Global motion perception (GMP) is an important aspect of visual perception. Numerous studies have found that GMP of cognitively healthy elderly declines with aging and it cannot be explained by age differences in the visual system. The neural mechanism of aging on GMP remains unclear. Resting-state fMRI has been widely used to detect the internal spontaneous activity of the aging brain. Thus, whether the functional activity of brain regions related to the GMP for the elderly in the resting state is an effective indicator of their global motion sensitivity (GMS) still needs further investigation. To reveal the neural basis of GMP decline for the elderly, the relationships between the resting-state functional activities of GMP related brain areas (Regions of Interest, ROI: V1, V2, V3, and MT/V5) and individuals’ motion coherence threshold (MCT) were analyzed by using rs-fMRI technology. In this study, Random Dot Kinematogram (RDK) paradigm was used to evaluate an individual’s GMS with the MCT as the indicator. A higher threshold of the RDK task meant lower sensitivity. Meanwhile, the rs-fMRI data of 36 younger adults (M = 22.04 years old) and 31 older adults (M = 65.05 years old) were acquired using rapid echo-planar imaging (EPI) sequence from a 3T Siemens Prisma magnetic resonance scanner, with TR=2s, TE=30ms, Time points=240 (young) or 246 (old). Rs-fMRI data were preprocessed and processed using SPM (http://www. fil.ion.ucl.ac.uk/spm) and DPABI (http://rfmri.org/dpabi) toolbox to obtain the functional activities of the ROIs, including ReHo, ALFF, voxel-wise FC, and ROI-wise FC. Then, the regional measures including three nodal centrality metrics (degree K, efficiency Enodal and betweenness b) and the global measures including small-world parameters (clustering coefficient Cp, characteristic path length Lp, normalized clustering coefficient γ, normalized characteristic path length λ, and small-worldness σ) and network efficiency (Global efficiency Eglob and Local efficiency Eloc) were calculated using GRETNA (http//www.nitrc.org/projects/gretna/) graph toolbox. To determine whether there were significant group differences in these functional properties, two-sample t-tests were performed on each metric. When significant between-group differences in any functional metrics were obtained, the Pearson correlation coefficients among these metrics and individuals’ MCT were further calculated to assess the relationship between changes in brain function and GMP aging. Results showed that 1) the ReHo values of right V3 and bilateral MT/V5 for older adults were significantly lower than that of younger adults, as well as the ALFF of bilateral MT/V5, and these functional metrics were significantly negatively correlated with individuals’ MCT; 2) The FCs between V2 and left primary motor cortex, V3 and left secondary visual cortex, MT/V5 and left premotor cortex, as well as the FCs between V1, V2, V3 and MT/V5 regions for the older adults were significantly stronger than that of younger adults, and these FCs were correlated with individuals’ MCT; 3) Older adults’ K, Enodal and b of most nodes in temporal lobe were significantly lower than younger adults, and the Enodal of the right temporal cortex were significantly negatively correlated with individuals’ MCT; 4) Older adults’ global network properties including small-world parameters (Cp, γ, Lp, λ, and σ) and network efficiency (Eglob and Eloc) were all significantly lower than younger adults’, with CP and Eloc significantly negatively correlated with their MCT. These findings suggested that the decline of GMS for the elderly was associated not only with functional changes in the dorsal visual pathway, especially in the MT/V5, but may also with functional changes in broader areas of the whole brain, which supported the theory of "dedifferentiation".
Peer Review Status:
Awaiting Review
Subjects: Psychology >> Educational Psychology submitted time 2020-05-07
Abstract： Statistical learning (SL), which was first addressed in the seminal study on speech segmentation of infants by Saffran et al. (1996), is a process of detecting the statistical regularities such as transitional probability in continuous flow of stimuli. Previous studies have proven the general existence of SL, and in recent years close attention has been placed on its specificity and its impact on other cognitive activities, especially revealing the cognitive neural mechanisms of SL and its interaction with language by exploring the process and the specificity of SL. According to the multimodal data from brain and behavior measures, future studies should seek more behavioral and neural indexes to evaluate the performance of SL, to explore the dynamic changes in neural activities of different types of SL and to construct the connection between neural correlates and behavioral performance, which will help to have an in-depth understanding of SL. Based on previous discoveries on the interaction between SL and language, future studies could determine whether SL is an effective intervention to improve language acquisition and how it works in the improvement, through exploring the effect of music SL training on second language learning of adult learners.
Peer Review Status:Awaiting Review
Subjects: Psychology >> Developmental Psychology submitted time 2019-09-28
Abstract： Brain imaging studies have found that the athletes engaged in racquet sports showed different brain structure and function based on expert-novice paradigm. However, the present findings cannot fully interpret the role of sport experience in brain plasticity. For example, it is still not clear whether such differences in brain structure are due to training experience or innate differences. The aim of the present study was to investigate whether young adults' brain structures are influenced by a short period of badminton training experience. A group of young adults (23 ~ 27 years) without any professional or amateur sports training were recruited to take part in the experiment. They were randomly divided into either the experimental group (21 non-athletes) or the control group (17 non-athletes). Participants in the experimental group were trained for 12 weeks (one hour each time and three times each week), and participants in the control group did not attend any regular sport trainings during this period. Structure imaging and diffusion tensor imaging (DTI) techniques were used to assess the effects of badminton training on the brain structural plasticity in young adults. T1 images and DTI data for all participants were collected before and after the intervention. Voxel-based morphometry (VBM) and Tract-based spatial statistics (TBSS) were used to perform a whole-brain analysis of the T1 and DTI data respectively. A 2 (participant group: experimental group, control group) × 2 (test time: pretest, posttest) repeated measure ANOVA was used to perform statistical analysis. The results showed that there were significant interactions between participant group and test time for the gray matter volume in the left inferior occipital lobe, middle temporal gyrus and inferior temporal gyrus. Specifically, participants in the experiment group exhibited increased gray matter volume in the above brain regions after the training, whilst participants in the control group showed decreased gray matter volume in the left middle temporal gyrus at posttest as compared to pretest. Furthermore, for the participants in the control group, there were no significant differences between pretest and posttest in the volume of left inferior occipital lobe and inferior temporal gyrus. In relation with the white matter microstructures, the experiment group had increased fractional anisotropy (FA) in the bilateral posterior limb of internal capsule and the superior corona radiate in posttest as compared to pretest. And the increased FA was induced by decreased radial diffusivity (RD). In contrast, the control group had decreased FA and increased RD in the above fibers at posttest relative to pretest. Taken together, these results suggest that badminton training increased the gray matter volume in the brain regions related to visual motion perception processing and increased the myelin sheath thickness of the fibers associated with motor learning. These results imply that in early adulthood, the gray matter and white matter of the brain might have plasticity to some extent.
Subjects: Biology >> Bioengineering submitted time 2019-01-17 Cooperative journals: 《中国生物工程杂志》
Abstract：固定化酶作为一种绿色高效的生物催化剂，其性能远超游离酶。目前酶的固定化技术适用范围仍然较小，酶的研究范围多停留在模型酶阶段，扩大固定化酶的研究范围具有十分重要的意义。金属有机骨架材料（MOFs）作为酶固定化的载体在近些年得到了广泛的探索，但是具有生物功能的酶-MOFs复合材料的许多特性仍有待挖掘。本文采用仿生矿化的合成方法将5-羟甲基糠醛氧化酶（HMFO）固定到以沸石咪唑酯（ZIF-8）为代表的MOFs材料中，制备得到一种新的生物催化剂HMFO@ZIF-8，扫描电子显微镜表征其形态区别于经典的菱形十二面体。采用考马斯亮蓝法测定蛋白质浓度，计算得到酶的固定化效率达到89.0%。HMFO@ZIF-8催化5-羟甲基糠醛的转化率达到84.3%，收率和选择性均高于游离酶。本文拓展了MOFs固定化酶的研究范围，为研究其他生物大分子复合材料的生物催化剂提供一定的借鉴意义。
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