Subjects: Statistics >> Social Statistics submitted time 2024-03-27 Cooperative journals: 《中国科学院院刊》
Abstract： In today’s rapidly advancing technological landscape, science communication is closely intertwined with technological innovation, serving as a crucial element in influencing a country’s technological competitiveness and competing for the global scientific and technological discourse. This study delves into the historical context of science communication and the theoretical research and paradigm shifts surrounding it. It explores the symbiotic relationship between science communication and technological innovation, uncovering the mechanisms of their interactions. On this basis, the study examines exemplary practices in promoting science communication in major developed countries. In light of China’s current state of science communication, tentative strategies are proposed to enhance the nation’s endeavors in the realm of science communication.
Subjects: Statistics >> Social Statistics submitted time 2024-03-27 Cooperative journals: 《中国科学院院刊》
Abstract： The measurement of national science and technology competitiveness helps to describe the international competition pattern, and to provide decision-making reference for future-oriented science and technology policy and strategy formulation. From the perspective of input-process-output, the study proposes a three-dimensional measurement framework of potential-efficiency-strength for national science and technology competitiveness and realizes a multi-dimensional comprehensive measurement of national science and technology competitiveness, which takes the differences in both scale and efficiency into account. Based on The Report on National Science and Technology Competitiveness 2023, the study measures the national science and technology competitiveness of 34 major countries in the world and focuses on the evolution trend of national science and technology competitiveness of 11 countries including China from 2011 to 2022. On this basis, the science and technology competitiveness of 34 countries is further classified and analyzed from the three dimensions of science and technology competitiveness potential, science and technology competitiveness effectiveness, and science and technology competitiveness strength, so as to describe the technological competition pattern of 34 countries and reveal the status quo of China’s science and technology competitiveness. The research has found that the growth rate of China’s science and technology competitiveness has gradually slowed down in recent years, shifting towards a stage of steady growth. However, there is still significant room for improvement compared to leading countries. Among them, the level of China’s science and technology competitiveness strength is relatively high, but the indicators that reflect the quality of China’s technological output are still far from those of major technological powers. China’s science and technology competitiveness potential has improved but the level of intensity indicators is still lower than those of main technological powers. The significant decrease in the science and technology competitiveness effectiveness compared to major technological powers is the main factor restricting the improvement of China’s science and technology competitiveness. Finally, this study puts forward suggestions to improve China’s science and technology competitiveness.
Subjects: Statistics >> Social Statistics submitted time 2024-03-27 Cooperative journals: 《中国科学院院刊》
Abstract： This study systematically summarizes the reports and speeches of the S70th Xiangshan Science Conferences on the theme of “Strategic Research on Information Technology Promoting the National Governance Modernization” and summarizes the consensus of the conference in the following three aspects. (1) Important progress and achievements have been made in the four typical areas, i.e., smart justice, internet governance, data governance, and emergency management. (2) Using information technology to promote the modernization of national governance is confronted with unprecedented opportunities and challenges. And (3) it is necessary to take a series of effective measures to promote information technology to facilitate the modernization of the national governance system and governance capacity from the top-level design.
Subjects: Library Science，Information Science >> Library Science submitted time 2023-08-27 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] Identifying the trajectory of development is of great importance to scientific and technological innovations. However, existing methods such as expert interviews and citation analysis cannot meet the current situation of the explosive growth of literature. In response to this problem, this paper proposes a new identification method of filed development trajectory. [Method/process] This method identifies the research topics and related scholars by using Kmeans ++ and spectral clustering algorithms with the keyword-scholar matrix, calculates the correlation between different topics, and finally visualizes the trajectory of developmen. [Result/conclusion] Through the empirical analysis of the field of artificial intelligence, the results show that the method can effectively reflect the evolution of the topic of field research, help researchers quickly locate popular research topics and focuses, and enrich the research methods related to the trajectory of field development.
Subjects: Management Science >> Other Disciplines of Management Science submitted time 2023-07-09 Cooperative journals: 《中国科学院院刊》
Abstract： Changes in international development environment such as geopolitics, geo-economics and science and technology innovation are reshaping the world’s competitive landscape and altering the balance of power among nations. China needs to adapt to the changes in international development environment, accurately grasp the new trends, optimize and adjust the science and technology strategy, effectively respond to new challenges, and seek new advantages in international competition. This study reviews China’s choices of science and technology strategy under the changes in international development environment. By summing up the successful experiences and remaining issues of the past science and technology strategies, the study proposes new choices for China’s science and technology strategy in response to new international development environment. It is found that, China’s science and technology strategy has been continuously adjusted and optimized in response to the ever-changing international development environment. Successful experience such as engaging in international scientific and technological cooperation, formulating forward-looking and systematic policies, improving the construction of national innovation system, fully leveraging the advantages of the nationwide system, or advancing reform of systems and mechanisms for science and technology, have effectively addressed the complex and changing international development environment and propelled the rapid development of China’s scientific and technological endeavors. However, China still needs to deal with and resolve the remaining issues in science and technology strategy choices, such as the path dependency of critical core technologies, the lack of deep integration between innovation and industrial, the lack of synergy among “education,science, technology and talent”, and the non-principal role of enterprises in innovation. Facing the new round of technological revolution and industrial transformation, the acceleration of deglobalization and regionalism, the rise of developing countries as a collective force, and the increasingly intense international conflicts and confrontations, China’s science and technology strategy should learn from historical retrospection and strengthen strategic foresight and form asymmetric advantages, enhance the development of a national self-reliant innovation ecosystem, and promote science, improve the new nationwide system to strengthen the basic capabilities of science and technology, and technology cooperation in the light of diverse international interests.
Subjects: Library Science，Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] With the proposal of the independent innovation strategy, the basic role of scientific and technological information in the development of national science and technology has been paid more and more attention. It is very necessary to carry out information service research and practice, and to build an information service method system and implementation plan for regional innovation and economic development.[Method/process] This article investigated the practice of domestic and foreign intelligence agencies serving regional innovation and economic development. Analyzed the overall design and service practices and cases of regional information services for the provincial academy of sciences, transfer centre of the Chinese Academy of Sciences, local government and enterprises of National Science Library, Chinese Academy of Sciences during the 12th and 13th Five-Year Plan. Summarized the characteristics and effectiveness of the regional innovation and economic development knowledge service carried out by the National Science Library.[Result/conclusion] On the basis of practice, we propose services for regional innovation and industrial development, which further expands the service area of the library. It is a growth point for the traditional library and will continue to develop and improve.
Subjects: Library Science，Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] This paper takes "Sci-Think" as an example to analyze the measures and results of emergency scientific communication services of the special libraries, and provides reference for scientific communication services of professional libraries in emergency situations.[Method/process] To sort out the service contents published by the "Sci-Think" WeChat public account during the epidemic, this paper analyzed users' attention to different types of contents from average daily user growth and reading volume, and put forward the thinking of emergency scientific communication services.[Result/conclusion] During the epidemic, Sci-Think's average daily user growth was obvious, with the highest reading volume of electronic resource protection content, followed by related content of the scientific and technological progress of COVID-19, and the number of popular science broadcasts and information quality education broadcasts exceeded tens of thousands. Under emergencies, special libraries should strengthen the promotion of special services, strengthen the information selection and review mechanism, and the lack of emergency scientific communication work plans in major public incidents also needs attention.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-28 Cooperative journals: 《中国科学院院刊》
Abstract： As digital technologies continue to be integrated into the whole process of economic and social development, promoting the modernization of digital technology-enabled national governance systems and capabilities has become an important way to seize the strategic initiative in the future world competitive landscape, and has attracted the attention of countries around the world. The rapid development of digital technologies such as big data collection, storage, processing, and analysis is constantly optimizing the organizational system structure of national governance, upgrading and perfecting the quality and methods of national governance personnel, and accelerating the process of making national governance efficient, scientific, intelligent and refined. At present, the national governance of China has made remarkable achievements but still faces many problems and challenges. The development of digital technologies for national governance needs scene expansion and talent supply, and the negative effects of digital technologies put new requirements on national governance. Based on the current development needs of the modernization of national governance supported by digital technology, this study puts forward suggestions to promote the modernization of national governance system and governance capacity endowed by digital technology, and quicken the pace to reach the overall goal of realizing the modernization of national governance.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-28 Cooperative journals: 《中国科学院院刊》
Abstract： Under the new situation, expanding and strengthening the crop seed industry and ensuring food security have been elevated to the national strategic importance. It urgently needs to improve the crop seed national innovation system and promote the deep integration of the innovation chain and industrial chain. The crop seed industry in developed countries such as the United States has formed a relatively mature industrial innovation system dominated by enterprises; however, China’s crop seed industry innovation system is large but weak, the seed industry innovation efficiency is low, and the innovation ecology of the innovation chain and the industrial chain integration is immature, which seriously restrict the high-quality development of China’s seed industry. Based on analyzing the development trend of the global crop seed industry and identifying the problems and obstacles restricting the integration of China’s seed industry innovation chain and industrial chain, it is suggested to fully consider the unique laws and needs of agricultural seed industry innovation, strengthen top-level design, optimize and integrate the national seed industry scientific and technological forces, and build a market-oriented, enterprise-centered, industry-university#2;research-government integration, and whole industry chain integration. The seed industry innovation system with Chinese characteristics fully utilizes the advantages of a unified large national market on the basis of fully considering regional differences, so as to promote the integration of the innovation chain and the industrial chain.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-28 Cooperative journals: 《中国科学院院刊》
Abstract： Based on the innovation value chain, this study establishes the “three horizontal and two vertical dimensions” measurement framework of National Innovation Force, which has a science-technology-industry horizontal dimension and a strength-effectiveness vertical dimension. The framework realizes a comprehensive analysis of National Innovation System from different perspectives and supports the categorized research and differentiated implementation of innovation policies and strategies. The framework considers the differences in science, technology, and innovation activities, as well as those between strength and effectiveness. Based on the analysis of 35 countries in The Report of National Innovation Force Measurement and International Comparison completed by the authors, this work studies in depth the evolution of National Innovation Force of China and ten typical countries from 2006 to 2020. In addition to the competitive landscape of National Innovation Force of 35 countries, it analyzes the advantages and disadvantages of China’s National Innovation Force during the period. As a result, it shows that the competitive landscape of National Innovation Force of 35 countries has changed slightly. China’s National Innovation Force ranking has increased steadily but still needs to be improved. From the comparison between China and ten typical countries, six developed countries, namely the United States of America, Japan, Germany, the United Kingdom, France, and South Korea, generally had high National Innovation Strength Force rankings. But their National Innovation Effectiveness Force rankings dropped from upper to the middle level, leading to the drop in National Innovation Force rankings of countries such as the United Kingdom and France in recent years. Four BRICS countries, namely South Africa, India, Brazil, and Russia were in the middle or lower level of National Innovation Strength Force rankings. Besides, their National Innovation Effectiveness Force ranked low, which restricted the improvement of their National Innovation Force rankings. China’s National Innovation Strength Force ranked among the top level of 35 countries and had obvious advantages. Despite some fluctuations, China’s National Innovation Effectiveness Force ranking rose to the middle level of 35 countries in 2020. However, China’s National Innovation Effectiveness Force ranking significantly lagged behind China’s National Innovation Strength Force ranking and restricted the improvement of China’s National Innovation Force ranking. From the perspective of three types of innovation activities, different from ten typical countries’ stable or declining trends, China’s National Technological Force ranking, National Scientific Force ranking, and National Industrial Force ranking were all on the rise. For China, the competitive advantage of National Technological Force became increasingly significant, while National Scientific Force was the key constraint force. In the future, some measures should be taken to enhance China’s National Innovation Force.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-01-28 Cooperative journals: 《中国全科医学》
Aili ZHANG
Qiqi HOU
Quanle HAN
Boheng ZHANG
Jiawei ZHANG
Hongxia CAO
Chao ZHANG
Shuohua CHEN
Shouling WU
Kangbo LI
Abstract：
Background The global population disease burden report shows that atrial fibrillation and chronic kidney disease (CKD) have become one of the fastest growing causes of death in the past 20 years. The concept of cardiorenal syndrome points out that atrial fibrillation may increase the risk of new-onset chronic kidney disease， but at present， there are few relevant studies on atrial fibrillation increasing the risk of new-onset chronic kidney disease at home and abroad， and the interaction between atrial fibrillation and age is not clear．Objective To investigate whether atrial fibrillation (AF) increases the risk of new-onset chronic kidney disease (CKD) in northern China. Methods Prospective cohort study was used to select the population (Kailuan population) (n=135168， age 18-98 years old) who participated in the health examination for employees of Kailuan Group in Hebei Province from June 2006 to October 2010， excluding 19883 people with missing data and CKD history， 4430 people with previous cerebrovascular and cardiovascular diseases， malignant tumors， AF during follow-up， and 110855 people finally， The patients were divided into AF group and non AF group according to whether they had AF or not， including 368 patients with AF and 110487 patients with non AF. The follow-up was conducted once a year. The final follow-up date was December 31， 2020， with a median follow-up of 13.46 (9.70，14.05) years. The end point was new-onset CKD. Statistically analyze whether AF affects the risk of new-onset CKD. Results (1) 368 patients (63.43±10.61) years old， 338 males (91.85%) in AF group; 110487 persons in non AF group， age (49.04±12.92)， male 88288 (79.91%); Comparison of age (years)， sex (male)， diastolic blood pressure (DBP)， systolic blood pressure (SBP)， body mass index (BMI)， total cholesterol (TC)， low-density lipoprotein cholesterol (LDL-C)， triglyceride (TG)，high-sensitivity C-reactive protein (Hs CRP)， education level (high school or above)， drinking， participating in physical exercise， hypertension， diabetes， taking antihypertensive drugs， taking hypoglycemic drugs between the atrial fibrillation group and the non atrial fibrillation group， The differences were statistically significant (P<0.01 or P<0.05); There was no significant difference in fasting blood glucose (FPG)， high-density lipoprotein cholesterol (HDL-C)， smoking， and taking lipid-lowering drugs between the AF group and the non AF group (P>0.05); (2) 95 new-onset cases of CKD in AF group， with a cumulative incidence rate of 30.40%; 110487 people in the non atrial fibrillation group， 22725 people with new-onset CKD， the cumulative incidence rate was 21.77%， and the cumulative incidence rate of the two groups was statistically significant (x2=14.30， P<0.001); The incidence density of AF group and non AF group was 28.63‰ person year and 18.48‰ person year respectively; (3) Compared with non AF group， AF group increased the risk of new CKD [HR=1.477，95% CI (1.208，1.806， P<0.001)]; Age stratification was performed. For people≤65 years old， AF increased the risk of new-onset CKD [HR=1.566，95% CI (1.024，2.035)， P=0.001]; For people over 65 years old， AF no longer increases the risk of CKD [HR=0.970，95% CI (0.707，1.330)， P=0.855]; After further adjustment of age， sex (male) by multivariate Cox proportional hazard regression analysis， AF no longer increased the risk of CKD in the whole population and the population over 65 years old [HR=1.167，95% CI (0.954，1.428)， P=0.133]， [HR=1.007，95% CI (0.734，1.381)， P=0.968]; For people≤65 years old， AF still increased the risk of CKD [HR=1.363，95% CI (1.048，1.769)， P=0.021]; After further adjusting for smoking， drinking， participating in physical exercise， high school and above education background， hypertension history， diabetes history， taking antihypertensive drugs， taking hypoglycemic drugs， taking lipid-lowering drugs， BMI， TG， HDL-C， LDL-C， FPG， Hs-CRP by multivariate Cox proportional hazard regression analysis， only people aged≤65 years old had AF increased the risk of CKD [HR=1.351，95% CI (1.038，1.755)， P=0.025].Conclusion AF is an independent risk factor for new-onset CKD in northern China， especially for young and middle-aged people≤65 years old.
Subjects: Biology >> Botany >> Applied botany submitted time 2021-12-19 Cooperative journals: 《广西植物》
Abstract： A number of Magnolia (Magnoliaceae) species bloom twice each year, instead of once in most other species in this family, which is a desirable ornamental trait. To investigate the molecular mechanism of the flower bud differentiation during the second bloom each year in these Magnolia species, quantitative real-time PCR (qRT-PCR) was frequently used as a sensitive gene expression technique that relies on the stability of reference genes for data normalization. Therefore, the identification of reference gene(s) suitable for molecular characterization during Magnolia flower bud differentiation in second bloom is of great interest. In this study, gene expression in the leaf and flower bud tissues of M. liliflora ‘Hongyuanbao’ at different stages of the flower bud differentiation during second bloom was analyzed. Based on transcriptomic sequencing data, eight constitutively expressed genes, including UBC (ubiquitinconjugating enzyme), ACT (actin), β-TUB (tubulin beta), β-TUB5 (tubulin beta), α-TUB3 (tubulin alpha), PEPC (phosphoenolpyruvate carboxylase), ACP2 (acyl carrier protein 2), ACP3 (acyl carrier protein 3), were selected as candidate reference genes for qRT-PCR. Comprehensively analysis was conducted using four softwares including geNorm, NormFinder, BestKeeper and RefFinder. Primer Premier 5 was used to design the primers. PCR products of all the eight candidate reference genes were analyzed by gel electrophoresis which showed sharp bands with the expected size. Each melting curve showed a single peak, which indicated the high specificity of PCR primers. The general assessment by the four different softwares ranked β-TUB, β-TUB5 and α-TUB3 as the most stable reference genes, whereas UBC and ACT were the lest stable. The reference genes were further evaluated by analyzing the relative expression of TFL1 gene with either single or in combination of β-TUB5, α-TUB3, β-TUB, which showed highly consistent results. In contrast, ACT and UBC did not effectively standardize the expression level of TFL1. In general, through this study, we have identified β-TUB5, α-TUB3 and β-TUB as the most suitable reference genes for qRT-PCR analysis of gene expression in flower bud differentiation during the annual second bloom of M. liliflora ‘Hongyuanbao’, which provides useful tools for investigating the regulatory mechanisms in Magnolia flowering.
Subjects: Psychology >> Cognitive Psychology submitted time 2021-10-13
Abstract： Physiognomy is an important factor in identifying and inferring the individual traits and behaviors. However, its internal mechanism still needs to be further explored. Based on general cognitive perspective and evolutionary cognitive perspective, then combined with the local and overall features of physiognomy, this paper expounds the process and effect of judging people by physiognomy. Based on the general cognitive perspective, physiognomy affects the recognition of individual traits through various cognitive processing systems, and these traits play important roles in judgment (ability, income, social hierarchy) and decision-making (trust, recruitment, promotion). Based on the perspective of evolutionary cognition, physiognomy plays an important role in evaluating individual health and genetic status through various evolutionary selection mechanisms, and thus has an important influence on judgment (marriage satisfaction, happiness, life satisfaction) and mate selection decision. In addition, the effect of physiognomy on individual life depends on the situations and individual traits. Future research should investigate the interaction among different physiognomy features, and explore the boundary conditions that influence the effect of facial recognition. Furthermore, it is necessary to improve the external validity of the research through big data analysis, and pay more attention to physiognomy features modified by epigenetics on individuals. It is also important to conduct research within the domestic context. In doing so, it will help enrich physiognomy-related research and build a more systematic physiognomy theory. " "
Subjects: Biology >> Botany >> Applied botany submitted time 2021-08-09 Cooperative journals: 《广西植物》
Abstract： UDP-flavonoid 3-O-glucosyltransferase (3GT) is one of the important catalytic enzymes in the anthocyanin biosynthesis pathway. To study the function of 3GT in anthocyanin biosynthesis of Magnolia liliflora, M. liliflora ‘Hongyuanbao’ was employed as materials. Primers were designed based on the 3GT sequence obtained from the transcriptome database of M. liliflora ‘Hongyuanbao’, and the structural gene Ml3GT1 in anthocyanin biosynthesis pathway was cloned by RT-PCR (reverse transcription-PCR), and its bioinformatics and expression pattern were analyzed. The results were as follows: (1) The cDNA of Ml3GT1 was 1 836 bp, and the open reading frame was 1 374 bp, encoding 457 amino acid residues. The relative molecular weight of Ml3GT1 was 49.37 kDa, and its isoelectric point was 6.04. (2) The deduced amino acid sequence of Ml3GT1 contains a conserved plant secondary product Glycosyltransferase signature sequence (PSPG box). (3) Results of the phylogenetic analysis showed that Ml3GT1 was closely relative to 3GT proteins from Freesia hybrida, Petunia × hybrida, and Ipomoea batatas. (4) Results of fluorescence quantitative PCR revealed that Ml3GT1 has spatio-temporal specificity, with the highest expression level in flowers, the lower expression level in young leaves and old leaves, and trace expression level in roots and stems; With the development of flowers, the expression level of Ml3GT1 gene decreased first, then increased, and showed the highest expression level at the fully-opening stage. These results suggest that Ml3GT1 may be involved in flavonoid glycosylation. This study will lay a foundation for the flower and color breeding of Magnolia plants.
Subjects: Hydraulic Engineering >> Basic Disciplines of Hydraulic Engineering submitted time 2021-02-22
Abstract： Quality and stability are the basic characteristics of the ecosystem, which comprehensively reflect the structure, process, and functional integrity of the ecosystem and the ability to resist interference, self-regulation, and dynamic balance. The Yellow River Basin is a complex giant system composed of many elements. The management and protection of the river basin ecosystem has received more and more attention. It is necessary to start from the integrity of the ecosystem, make overall considerations, and implement comprehensive policies to improve the quality and stability of the ecosystem, and promote a virtuous cycle of the ecosystem, so the quantitative description of system quality and stability is very important. This paper uses the entropy weight model to establish a multi-index long-term series of Ecosystem Quality Index (EQI) to quantitatively describe the changes in ecological quality in the Yellow River Basin in the past 40 years; at the same time, use the dissipative structure theory and the Brussels model to establish the steady-state transformation of the ecosystem Quantitative indicators and methods provide ideas for the study of steady-state transformation of the Yellow River Basin ecosystem. The study found that: (1) The average EQI value of the Yellow River Basin ecosystem over the past 40 years is 0.64, the maximum value is 0.70, and the minimum value is 0.59. The overall quality is showing an oscillating trend for improvement; (2) The steady-state conversion power value of the system is less than 0, indicating that the steady-state conversion power of the ecological-human-society coupling system in the Yellow River Basin is low, but the overall trend is oscillating upward, and the overall trend is getting closer and closer to the critical conditions for achieving steady-state conversion.
Peer Review Status:
Awaiting Review
Subjects: Hydraulic Engineering >> Basic Disciplines of Hydraulic Engineering submitted time 2021-01-25
Abstract： The ecological environment of the Yellow River Basin is systematic and complicated. It is of great significance to study the quantitative evaluation and change characteristics of the Yellow River Basin by providing scientific basis on integrated river basin management. This in one of the current widespread concerns and urgent problems to be solved. Through calculating the entropy weights of eco-environmental indicators in Yellow River Basin from 1980 to 2019, the dynamic entropy weight results were verified. Then the importance of the individual indicator in system was proved to be variable. On this basis, the EDIs (Environment Development Indexes) of the Yellow River Basin from 1980 to 2019 were analyzed and plotted by curve, which valued between 56.64～76.60. The changing trend of EDI in the Yellow River Basin was almost presented stabilized before 2003, and continuously increasing from 2003. The results show that through the years of protection and restoration, the ecological negative feedback was exerted profound effect, resulting the ecological environment of the Yellow River Basin was changing well.
Peer Review Status:Awaiting Review
Subjects: Geosciences >> Other Disciplines of Geosciences submitted time 2019-09-11 Cooperative journals: 《干旱区研究》
Abstract：通过野外试验探究了流动沙丘中上部导风板板后作用区风速特性和输沙量特征，结果表明：不同角度导风板对板后风速增加的区域有所不同，作用区内最大风速一般出现于板后1.5 m，45°导风板对于板后1.5 m处风速加速效果明显，板后3.0 m处则是25°导风板加速效果较为明显，而在板后4.5 m处影响效果明显的导风板角度为35°。导风板可以有效的提高板后输沙总量，其中30°~45°区间的中等角度导风板对于输沙量的提升具有明显效果，45°导风板对于板后1.5 m处输沙量提升效果较高，而40°导风板对于板后3.0 m处输沙量提升效果较高，在板后4.5 m处则是30°导风板提升效果较高。
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2018-01-25 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To evaluate the effect of ulinastatin on hypoxia-induced phenotype modulation of pulmonary artery smooth muscle cells (PASMCs) and explore the underlying mechanism. Method Cultured PASMCs from SD rats were exposed to normoxic condition, normoxia with ulinastatin treatment, hypoxia, or hypoxia with ulinastatin treatment. After 24 h of exposures, the cells were examined for SM-α-actin and caplonin expressions with immunofluorescence assay and for cell migration with CCK-8 and 3H-TdR assays. Western blotting was used for detecting the expressions of PPAR-γ in the cells, and PPAR-γ-responsive firefly luciferase reporter was employed for measuring the transcriptional activity of PPAR-γ. The PPAR-γ inhibitor GW9662 was used to explore the mechanism of the inhibitory effect of ulinastatin on hypoxia induced-phenotype modulation of PASMCs by measuring the changes in cell proliferation and migration. Results Ulinastatin obviously enhanced the expressions of SM-α-actin and calponin (P<0.05), inhibited the proliferation and migration (P<0.05), and up-regulated the expression of PPAR-γ in PASMCs exposed to hypoxia (P<0.05). Pretreatment of the cells with GW9662 abolished the effect of ulinastatin on hypoxia-induced phenotype modulation of PASMCs and enhanced the cell proliferation and migration (P<0.05). Conclusion Ulinastatin inhibits hypoxia-induced phenotype modulation of PASMCs from rats possibly by up-regulating the expressionofPPAR-γ.
Subjects: Dynamic and Electric Engineering >> Engineering Thermophysics submitted time 2017-11-07 Cooperative journals: 《工程热物理学报》
Abstract：大气中水蒸气会影响气溶胶颗粒的生长演化动力学特性，从而改变其环境效应。当前，对包含有机组分气溶胶颗粒与水相互作用机理的认识还很局限。本文建立了纯有机气溶胶和有机一无机混合气溶胶颗粒水溶特性研究分子动力学模型，分别模拟了不同温度条件下不同卤化钠盐(Na工/NaCl/NaF)对丙二酸(C3H40户团簇水溶特性的影响情况。重点分析了各影响因素作用下团簇结构和气粒界面特性。结果表明，温度升高，C3H404 H}O团簇相继出现分层结构和混合结构。加入40个卤化钠分子后，水分子对初始团簇溶解程度的排序为40NaF<40NaCl
Subjects: Astronomy >> Astrophysical processes submitted time 2017-10-20 Cooperative journals: 《天文研究与技术》
Abstract：天体视位置是进行天文定姿的必备数据，目前视位置计算的研究多基于地面和海上，天基平台的发展需进一步研究。介绍了星上视位置转换原理，推导各种位置改正公式，基于新天文参考框架建立一种太阳系内天体视位置计算模型，可计算任意时刻天体的地心视位置和站心视位置。与天文年历地心视位置相比，类木行星的赤经差值在10 ms以内，赤纬差值在220 mas以内;与STK仿真的站心视位置相比，赤经差值在0.15s以内，赤纬差值在2"以内。实验表明，该模型可以正确计算测瞬太阳系内天体的视位置，其精度满足天文定姿的需求。
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