Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2024-01-11 Cooperative journals: 《中国全科医学》
Abstract： Background Benign paroxysmal positional vertigo（BPPV）is a common clinical disease characterized by self-limiting and easy recurrence. Manual reduction is effective but residual symptoms may occur in some patients after reduction. In recent years，there are many studies focus on the influencing factors of therapeutic efficiency of BPPV，while the comparison among specific causes and factors influencing residual symptoms remain to be further investigated. Objective To analyze the clinical features of secondary BPPV，investigate the effect of etiological classification of BPPV on the recurrence rate，and clarify the risk factors of residual symptoms after BPPV reduction. Methods A total of 340 patients diagnosed with BPPV were enrolled in the vertigo clinic of the department of otorhinolaryngology head and neck surgery department and otology department of the First Hospital of Jilin University from April 2019 to April 2021，and all of them agreed to manual reduction. The included patients were divided into the primary BPPV（the primary group）and secondary BPPV（the secondary group）groups according to the presence or absence of primary disease. The secondary group was further divided into five subgroups according to different etiologies，included sudden sensorineural hearing loss（SSNHL），vestibular migraine（VM），Ménière disease（MD），vestibular neuritis（VN），and others（such as cranial and ear surgery，Hunt syndrome，temporal bone fracture，etc.）. The clinical features and prognosis were compared between the primary group and secondary group. Follow-up to 3 months after the first reduction，the patients were divided into the residual symptom group and non-residual symptom group according to the occurrence of residual symptoms. The differences were compared in clinical characteristics and scores of Self-rating Anxiety Scale（SAS）and Self-rating Depression Scale（SDS）at different time periods（at diagnosis，4 weeks after treatment，and 3 months after treatment）between the two groups，and the independent risk factors of residual symptoms after BPPV reduction were analyzed. Results Among the 340 patients，184（54.1%）were in the primary group and 156（45.9%）were in the secondary group. Compared with the primary group，the patients of the secondary group was younger，and the proportion of patients who underwent more than two reductions was higher，the success rate of the first reduction was lower；and the recurrence rate within 3 months，incidence of residual symptoms，SAS score at diagnosis，and SDS score at diagnosis in the primary group were higher than those in the secondary group，with significant differences（P<0.05）. There were statistically significant differences in the age of patients with different etiologies of secondary BPPV（P<0.05），and the age of patients with other etiologies（such as cranial and ear surgery，Hunt syndrome，temporal bone fracture，etc.）was lower than that of patients with SSNHL，VM，MD，and VN groups（P<0.05）. There were no significant differences in gender，semicircular canal involvement，number of reductions，success rate of the first reduction，recurrence rate within 3 months，incidence of residual symptoms，SAS and SDS scores at different time among different etiology groups of secondary BPPV（P>0.05）. There were 133 patients in residual symptom group and 207 patients in the non-residual symptom group. The main residual symptoms were dizziness（59.4%，79/133），instability（24.06%，32/133）and head and neck discomfort（9.77%，13/133），and 6.77%（9/133）had two or more symptoms. The proportion of secondary BPPV and more than two reductions in the residual symptom group was higher than that in the non-residual symptom group（P<0.05），and the proportion of recurrence was less，the SAS and SDS scores at diagnosis，4 weeks after treatment，and 3 months after treatment were higher than those in the non-residual symptom group（P<0.01）.The results of multivariate Logistic regression analysis showed that SAS score at diagnosis（OR=1.231，95%CI=1.117-1.357，P<0.001）and SDS score at diagnosis（OR=1.209，95%CI=1.113-1.314，P<0.001）were risk factors for the occurrence of residual symptoms after reduction in BPPV patients. Conclusion Secondary BPPV is characterized by a high incidence of residual symptoms and recurrence rate after reduction. The anxiety and depression can affect the occurrence of residual symptoms after reduction.
Subjects: Physics >> Nuclear Physics submitted time 2023-10-07
Abstract： The measurement of the muonic hydrogen atom Lamb shift is one of the most fundamental ways to obtain the proton charge radius experimentally. The theoretical calculation of the muonic hydrogen atom Lamb shift is necessary to extract the proton charge radius from the Lamb shift. In this work, we calculate the muonic hydrogen atom Lamb shift within the relativistic framework. The relativistic effect is described with the Breit-Pauli hamiltonian. The vacuum polarization effect is realized with the effective Uehling potential. With a high precision calculational method, Gaussian expansion method, we calculate the 2S1/2 and 2P1/2 levels of the muonic hydrogen atom. We find that the muonic hydrogen atom Lamb shift with considering the relativistic effect is about 0.09 meV larger than the one without considering the relativistic effect and the former one is closer to the experimental value.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2023-09-17
Abstract： Objective To study the expression of SMARCA4, BRAF, p53, programmed death receptor 1 (PD-1) and its ligand 1 (PD-L1), and BRAF and neurotrophin tyrosine kinase receptor (NTRK) genes changes in colorectal cancer in Tibet. Methods A total of 64 patients with colorectal cancer resected in Autonomous Region People's Hospital from January 2015 to July 2021 was enrolled in this study. The expression of SMARCA4, BRAF, p53, PD-1, PD-L1 was detected by immunohistochemical(IHC) staining, and detection of NTRK1, NTRK2, NTRK3 fusion gene by fluorescence in situ hybridization (FISH), BRAF V600E gene mutation by polymerase chain reaction (PCR). Results 64 cases of colorectal cancer, with a male to female ratio of 1.21:1 and the mean age of (56.59 ± 13.27) years. 46 cases (46/64, 71.88%) were located in the colon, and 18 cases (18/64, 28.12%) were in the rectum. 60 cases (60/64, 93.75%) were adenocarcinoma, and 4 cases (4/64, 6.25%) were other types. 11 cases (11/64, 17.19%) were in T1 or T2 phase, and 53 cases (53/64, 82.81%) were in T3 or T4 phase; 24 cases (24/64, 37.50%) were found lymph node metastasis. The IHC staining showed that SMARCA41 was partial expression reduced or missing in a case (1/64, 1.56%), BRAF were positive in 4 cases (4/64,6.25%), p53 showed mutant expression pattern in 35 cases (35/64,54.69%). PD-1 expression <10% of tumour background immune cells in 45 cases (45/64,70.31%) , and ≥ 10% in 19 cases（19/64,29.69%）. PD- L1 proportion Score （CPS）<10 in 52 cases(（52/64，81.25%）, and ≥ 10 in 12 cases（12/54,18.75%）.None case was detected the fusion genes of NTRK1, NTRK1, and NTRK1, and four cases were detected BRAF V600E gene mutations. No SMARCA4 gene changes was detected in one case with SMARCA4 partial expression missing. The difference between the PD-L1 expression proportion score and the status of mismatch repair /microsatellite instability (MMR/ MSI), as well as the expression level of PD-1 was statistically significant (P=0.001). Conclusions SMARCA4 expression reduced or missing and NTRK fusion gene are rare in colorectal cancer in Tibet. A few cases have BRAF V600E gene mutations, and Pan-TRK and BRAF expression can be used as initial screening methods for NTRK fusion gene and BRAF gene mutation. Cases with mismatch repair deficiency / microsatellite instability-high (dMMR/MSI-H) are more prone to high expression of PD-L1 protein, and the patients with dMMR/MSI-H may benefit from immunotherapy. The high expression of PD-1 is positively correlated with the high expression of PD-L1.
Peer Review Status:
Awaiting Review
Subjects: Nursing >> Nursing submitted time 2023-04-24
Abstract： Objective To evaluate the application and nursing effects of M3 machine nickel-titanium file in one-time root canal therapy for the elderly patients. Methods Totally 160 elderly patients with chronic pulpitis who needed root canal therapy were treated with one-time root canal therapy. They were randomly divided into two groups with 80 cases in each group, including premolars and molars. In the experimental group, the root canals were prepared with M3 nickel-titanium rotary instruments (M3-Path file and M3 Pro file). In the control group, the root canals were dredged and prepared with traditional hand root canal instruments (C-file and K-file). The treatment time and postoperative pain between the two groups were compared. This paper also expounded the factors concerned by nurses about nursing before, during and after treatment. Results A shorter time of premolar and molar root canal preparation was observed in the experimental group than that in the control group (P＜0.05). The outcome of postoperative pain assessment of the experimental group was significantly lower than that of the control group (P＜0.05). Conclusion The use of nickel titanium file for M3 machine combined with high-quality nursing can significantly shorten the root canal preparation time and reduce postoperative pain response, showing a positive value of shortening the time required for nurses'' chair cooperation, improving clinical work efficiency and making patients get more satisfactory medical services.
Peer Review Status:Awaiting Review
Subjects: Nursing >> Nursing submitted time 2023-04-24
Abstract： Objective To evaluate the nursing cooperation in root canal retreatment of infected root canal. Methods Totally 60 patients with infected root canals of molar teeth requiring root canal retreatment were randomly divided into the control group and observation group, with 30 cases in each group. All patients received routine nursing during the treatment, and those in the observation group were given refined nursing management. The operation time was recorded and compared between two groups. Results The operation time of the observation group was significant shorter than that of control group, with a significant difference(P＜0.05). Conclusion A comprehensive and refined management of nursing cooperation may help shorten the operation time of root canal retreatment, reduce the risk of infection, relieve of fatigue of both dentists and patients, and improve the comfort of patient during the treatment.
Peer Review Status:Awaiting Review
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-28 Cooperative journals: 《中国科学院院刊》
Abstract： Lakes in the Yangtze River Economic Belt are mainly distributed in the Hengduan Mountain area in Southwest China and the flood plain area of the Yangtze-Huaihe River Basin in East China. The high spatial variability of natural environment and economic development have rendered the ecological and environmental problems of these lakes. Comprehensive improvement of the lake environment and their ecological states are important for regional development. In the absence of long-term monitoring data, past environmental changes based on lake sediments, also termed as paleolimnological studies, can provide historical information for the protection and restoration of these lakes. This study revealed better water quality in alpine lakes than low-altitude ones in southwest China, while the worst water quality in the shallow lakes in the Jianghuai region. Furthermore, based on paleolimnological analysis, this study provided a long-term perspective to reveal the evolution characteristics and the mechanisms responding to the changes in climate, hydrology and nutrition in different lakes of the two areas in the past century. Such research also elucidated the reasons of the lake degradation in recent years, and exhibited the advantage of paleolimnological studies in defining reference conditions for ecosystem restoration, management evaluation, community structure optimization during aquatic vegetation restoration, early warning signals of ecosystem critical transition, and ecological safety assessment. Aiming at above environmental problems faced by lakes in different regions, the study put forward several targeted measures for their protection and restoration.
Subjects: Library Science，Information Science >> Information Science submitted time 2023-03-13
Zhang Zhixiong
Qian Li
Xie Jing
Chang Zhijun
Liu Yi
Yu Gaihong
Hu Maodi
Wang Lu
Li Xuesi
Zhao Yang
Wang Yufei
Wang Meng
Lin Xin
Zhang Mengting
Li Yang
Zhang Qin
Wang Yajiao
Guan Zhengyi
Meng Xu
Wu Xinyu
Abstract： ChatGPT is a dialogue system developed by OpenAI company. It appears as a Chatbot, but in essence, it uses Artificial Intelligence Generated Content (AIGC) technology to produce answers. Its key foundation is Generative Pre-trained Transformer and the core technology is InstructGPT. When compared to similar products in the early stages, its main characteristic is that there is a significant decrease in making up facts and generating toxic content. We present a systematic investigation of the technical structure, relevant research and practice, and applications scenarios of ChatGPT. Based on the investigation, we analyze the inspiration from the rapid development of AI technology as well as the influence of ChatGPT on Scientific Research and Library & Information Service. According to these influence, we present eight suggestions for the Library & Information Service field. Overall, the field should find its distinctive value orientation in the AI era, not only by maintaining the conventional scientific research paradigm, but also by exploring new technologies to boost scientific research.
Peer Review Status:Awaiting Review
Subjects: Psychology >> Developmental Psychology submitted time 2021-12-15
Abstract： This systematic review aimed to explore the predictive role of childhood unpredictability on youth development performance from the perspective of life history theory. Methods: Relevant literatures in the field of life history theory were retrieved with subject retrieval method, searching the key words with childhood unpredictability and youth development performance from the database of Web of Science, ProQuest, SpringerLink, PubMed, ScienceDirect, CNKI, VIP and Wanfang Data. The inclusion criteria were peer reviewed, longitudinal or retrospective studies, including measures of environmental unpredictability, and including measures of developmental performance. 22 articles met the inclusion criteria. Results: The higher childhood unpredictability youth experienced, the more negative development performance associated with reproduction, specifically reflected in the aspects of reproductive development, romantic relationship and parenting characteristics. There are also different effects on physical and mental health, social adjustment, cognitive function, personality traits and problem behavior. Conclusion: Childhood unpredictability could predict the developmental performance of youth. There may be a sensitive period in the prediction effect, and gender differences and individual differences are also existed. Outlook: Research on subjective perception assessment of environmental risk should be carried out in the future, and attention should be paid to the childhood unpredictability’s concept construction and measurement based on Chinese culture. In addition, research on protective factors such as the way breaking intergenerational cycle are also essential, which may break off negative developmental manifestations. " " " " "
Peer Review Status:Awaiting Review
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2019-11-15 Cooperative journals: 《协和医学杂志》
Abstract：患者男性，87岁，主诉“皮疹1月余，胸闷伴少尿11天”，于2019年4月29日收住北京协和医院老年医学科。
Subjects: Computer Science >> Integration Theory of Computer Science submitted time 2019-01-28 Cooperative journals: 《计算机应用研究》
Abstract： Study the problem of secure subset, most of the existing protocols that solve such problems can only keep the elements of one set private, therefore, it has great practical significance to study this kind of problem. Under the semi-honest model, this paper constructed a secure subset protocol by using Bloom filter and Goldwasser-Micali homomorphic encryption algorithm, and proved the security of the protocol by using common simulation examples in secure multi-party computing. It used the Bloom filter to map a data set with a large number or large number field elements into a smaller data set, improved the efficiency and range of the protocol, at the same time, it used the Goldwasser-Micali homomorphic encryption algorithm to ensure the security of the protocol. Most of the relevant researches are based on the difficult problems such that secondary residuals, it is impossible to resist quantum attacks, and the secure subset computation which can resist quantum attacks is a further research direction.
Subjects: Biology >> Zoology submitted time 2018-12-24 Cooperative journals: 《动物营养学报》
Abstract：本试验旨在研究饲粮不同谷氨酸和天冬氨酸水平对仔猪器官指数、血清生化指标和激素含量的影响。选取42头35日龄健康三元（杜×长×大）杂交断奶仔猪，随机分为6组，每组7个重复，每个重复1头猪。对照组（NC组）饲粮谷氨酸和天冬氨酸水平分别为2.9%和1.5%，其余各组在NC组的基础上调整饲粮谷氨酸和天冬氨酸水平分别为2.9%和1.3%（LA组）、2.9%和1.7%（HA组）、2.6%和1.5%（LG组）、3.2%和1.5%（HG组）、3.5%和1.5%（HHG组）。试验期为21 d。于试验结束时测定仔猪器官指数、血清生化指标和激素含量。结果表明：1）饲粮不同谷氨酸和天冬氨酸水平对仔猪各器官指数均无显著影响（P>0.05）。2）LA组和NC组血清甘油三酯含量显著低于HA组(P<0.05)，HG组和HHG组血清甘油三酯含量显著低于LG组(P<0.05)，LG组血清白蛋白含量显著低于NC组和HG组(P<0.05)，LG组和HG组血清葡萄糖含量显著低于HHG组(P<0.05)。3）HA组血清胃抑素含量显著低于LA组(P<0.05)，LG组和HG组血清胰岛素含量显著高于HHG组(P<0.05)，LG组和HG组血清胰高血糖素含量显著低于HHG组(P<0.05)，LG组和NC组血清生长激素含量显著低于HHG组(P<0.05)。由此可见，饲粮不同谷氨酸和天冬氨酸水平影响了仔猪血清生化指标和激素含量，但是对器官发育无显著影响。
Subjects: Biology >> Zoology submitted time 2018-12-24 Cooperative journals: 《动物营养学报》
Abstract：本试验旨在研究饲粮不同谷氨酸和天冬氨酸水平对仔猪器官指数、血清生化指标和激素含量的影响。选取42头35日龄健康三元（杜×长×大）杂交断奶仔猪，随机分为6组，每组7个重复，每个重复1头猪。对照组（NC组）饲粮谷氨酸和天冬氨酸水平分别为2.9%和1.5%，其余各组在NC组的基础上调整饲粮谷氨酸和天冬氨酸水平分别为2.9%和1.3%（LA组）、2.9%和1.7%（HA组）、2.6%和1.5%（LG组）、3.2%和1.5%（HG组）、3.5%和1.5%（HHG组）。试验期为21 d。于试验结束时测定仔猪器官指数、血清生化指标和激素含量。结果表明：1）饲粮不同谷氨酸和天冬氨酸水平对仔猪各器官指数均无显著影响（P>0.05）。2）LA组和NC组血清甘油三酯含量显著低于HA组(P<0.05)，HG组和HHG组血清甘油三酯含量显著低于LG组(P<0.05)，LG组血清白蛋白含量显著低于NC组和HG组(P<0.05)，LG组和HG组血清葡萄糖含量显著低于HHG组(P<0.05)。3）HA组血清胃抑素含量显著低于LA组(P<0.05)，LG组和HG组血清胰岛素含量显著高于HHG组(P<0.05)，LG组和HG组血清胰高血糖素含量显著低于HHG组(P<0.05)，LG组和NC组血清生长激素含量显著低于HHG组(P<0.05)。由此可见，饲粮不同谷氨酸和天冬氨酸水平影响了仔猪血清生化指标和激素含量，但是对器官发育无显著影响。
Subjects: Computer Science >> Integration Theory of Computer Science submitted time 2018-04-19 Cooperative journals: 《计算机应用研究》
Abstract： For the unscented fast simultaneous localization and mapping (Unscented FastSLAM) algorithm in robot navigation, the sample particle is degraded due to resampling, which leads to the problem of reduced accuracy. In order to solve the problem, this paper developed an improved Unscented FastSLAM algorithm based on adaptive fading unscented particle filter. The algorithm merged the unscented particle filter with the fading filter to form adaptive proposed distribution function. At the same time, the particles were optimally combined according to their weight, and only unstable particles are resampled. Through these two aspects could make the system highly adaptive, while ensuring the diversity of particles and mitigating the degradation of particles. Simulation experiments show that compared with Unscented FastSLAM algorithm, the proposed algorithm can achieve higher SLAM estimation accuracy with fewer particles, which greatly reduces the complexity of SLAM algorithm.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2018-01-25 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate the changes in the population and distribution intestinal microflora and their relationship with depression in post-stroke patients. Method Fecal specimens were obtained from 32 patients with post-stroke depression and 30 healthy adults for gene sequencing of 16S RNA V3 region of the intestinal microorganism using Roche/45 high-throughput sequencing platform. Results The genus and species of intestinal bacteria showed significant differences between the post-stroke patients and health adults. Conclusion Significant changes in the structure of intestinal flora occur in patientswithpost-strokedepression.
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